Literature summary for 5.1.3.7 extracted from

Winans, K.A.; Bertozzi, C.R.
An inhibitor of the human UDP-GlcNAc 4-epimerase identified from a uridine-based library: a strategy to inhibit O-linked glycosylation (2002), Chem. Biol., 9, 113-129.

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Inhibitors

Inhibitors	Comment	Organism	Structure
5'-{(E)-[(6-bromo-2-hydroxynaphthalen-1-yl)methylidene]amino}-5'-deoxyuridine	IC50: 0.025 mM, specific for UDP-GlcNAc 4-epimerase, powerful reagent for reversible inhibition of O-linked glycosylation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant enzyme	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.011	-	5'-{(E)-[(6-bromo-2-hydroxynaphthalen-1-yl)methylidene]amino}-5'-deoxyuridine	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.025	-	IC50: 0.025 mM, specific for UDP-GlcNAc 4-epimerase, powerful reagent for reversible inhibition of O-linked glycosylation	Homo sapiens	5'-{(E)-[(6-bromo-2-hydroxynaphthalen-1-yl)methylidene]amino}-5'-deoxyuridine

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Release 2023.1 (January 2023)