BRENDA - Enzyme Database show
show all sequences of 5.1.3.29

Characterization and role of fucose mutarotase in mammalian cells

Park, D.; Ryu, K.S.; Choi, D.; Kwak, J.; Park, C.; Glycobiology 17, 955-962 (2007)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression in Escherichia coli, cloned into pcDNA3.1 plasmid and transfected into HepG2 cells
Homo sapiens
expression in Escherichia coli, cloned into pcDNA3.1 plasmid and transfected into HepG2 cells
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
alpha-L-fucopyranose
Mus musculus
the enzyme is involved in an interconversion between the two anomeric forms. The enzyme is functional in facilitated incorporation of fucose through the salvage pathway
beta-L-fucopyranose
-
-
r
alpha-L-fucopyranose
Homo sapiens
the enzyme is involved in an interconversion between the two anomeric forms. The enzyme is functional in facilitated incorporation of fucose through the salvage pathway
beta-L-fucopyranose
-
-
r
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
A2VDF0
-
-
Mus musculus
Q8R2K1
-
-
Purification (Commentary)
Commentary
Organism
-
Homo sapiens
-
Mus musculus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
kidney
-
Mus musculus
-
liver
-
Mus musculus
-
muscle
marginal expression
Mus musculus
-
pancreas
-
Mus musculus
-
small intestine
-
Mus musculus
-
testis
marginal expression
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
alpha-L-fucopyranose
the enzyme is involved in an interconversion between the two anomeric forms. The enzyme is functional in facilitated incorporation of fucose through the salvage pathway
725106
Mus musculus
beta-L-fucopyranose
-
-
-
r
alpha-L-fucopyranose
the enzyme is involved in an interconversion between the two anomeric forms. The enzyme is functional in facilitated incorporation of fucose through the salvage pathway
725106
Homo sapiens
beta-L-fucopyranose
-
-
-
r
alpha-L-fucopyranose
an exchange rate of alpha-to-beta conversion of L-fucose in the absence of FucU is extremely slow
725106
Mus musculus
beta-L-fucopyranose
-
-
-
r
Subunits
Subunits
Commentary
Organism
More
mainly homodimer, but exists also as homotetramer, homooctamer, and homodecamer. The homodimeric form seems to be catalytically inactive
Mus musculus
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Escherichia coli, cloned into pcDNA3.1 plasmid and transfected into HepG2 cells
Homo sapiens
expression in Escherichia coli, cloned into pcDNA3.1 plasmid and transfected into HepG2 cells
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
alpha-L-fucopyranose
Mus musculus
the enzyme is involved in an interconversion between the two anomeric forms. The enzyme is functional in facilitated incorporation of fucose through the salvage pathway
beta-L-fucopyranose
-
-
r
alpha-L-fucopyranose
Homo sapiens
the enzyme is involved in an interconversion between the two anomeric forms. The enzyme is functional in facilitated incorporation of fucose through the salvage pathway
beta-L-fucopyranose
-
-
r
Purification (Commentary) (protein specific)
Commentary
Organism
-
Homo sapiens
-
Mus musculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
kidney
-
Mus musculus
-
liver
-
Mus musculus
-
muscle
marginal expression
Mus musculus
-
pancreas
-
Mus musculus
-
small intestine
-
Mus musculus
-
testis
marginal expression
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
alpha-L-fucopyranose
the enzyme is involved in an interconversion between the two anomeric forms. The enzyme is functional in facilitated incorporation of fucose through the salvage pathway
725106
Mus musculus
beta-L-fucopyranose
-
-
-
r
alpha-L-fucopyranose
the enzyme is involved in an interconversion between the two anomeric forms. The enzyme is functional in facilitated incorporation of fucose through the salvage pathway
725106
Homo sapiens
beta-L-fucopyranose
-
-
-
r
alpha-L-fucopyranose
an exchange rate of alpha-to-beta conversion of L-fucose in the absence of FucU is extremely slow
725106
Mus musculus
beta-L-fucopyranose
-
-
-
r
Subunits (protein specific)
Subunits
Commentary
Organism
More
mainly homodimer, but exists also as homotetramer, homooctamer, and homodecamer. The homodimeric form seems to be catalytically inactive
Mus musculus
General Information
General Information
Commentary
Organism
physiological function
the mammalian mutarotase is functional in facilitated incorporation of fucose through the salvage pathway
Homo sapiens
physiological function
the mammalian mutarotase is functional in facilitated incorporation of fucose through the salvage pathway
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
the mammalian mutarotase is functional in facilitated incorporation of fucose through the salvage pathway
Homo sapiens
physiological function
the mammalian mutarotase is functional in facilitated incorporation of fucose through the salvage pathway
Mus musculus
Other publictions for EC 5.1.3.29
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
723846
Higgins
Structure of the fucose mutaro ...
Streptococcus pneumoniae
Acta Crystallogr. Sect. F
67
1524-1530
2011
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1
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724666
Park
Male-like sexual behavior of f ...
Mus musculus
BMC Genet.
11
62
2010
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1
1
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725706
Lee
Crystal structures and enzyme ...
Escherichia coli, Mus musculus
J. Mol. Biol.
391
178-191
2009
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2
2
3
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1
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725106
Park
Characterization and role of f ...
Homo sapiens, Mus musculus
Glycobiology
17
955-962
2007
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2
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2
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2
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6
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1
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2
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6
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1
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2
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725359
Ryu
NMR application probes a novel ...
Escherichia coli
J. Biol. Chem.
279
25544-25548
2004
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2