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Literature summary for 5.1.3.18 extracted from

  • Gilbert, L.; Alhagdow, M.; Nunes-Nesi, A.; Quemener, B.; Guillon, F.; Bouchet, B.; Faurobert, M.; Gouble, B.; Page, D.; Garcia, V.; Petit, J.; Stevens, R.; Causse, M.; Fernie, A.R.; Lahaye, M.; Rothan, C.; Baldet, P.
    GDP-D-mannose 3,5-epimerase (GME) plays a key role at the intersection of ascorbate and non-cellulosic cell-wall biosynthesis in tomato (2009), Plant J., 60, 499-508.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information construction of transgenic tomato lines RNAi-silenced for GME, RNAi silencing of GME in tomato effectively reduces ascorbate content in the plant, leading to ROS accumulation, leaf bleaching and developmental defects. Transgenic plants display strong alterations in cell-wall composition, with a considerable impact on plant and fruit mechanical properties, GME-silenced lines have increased fragility, phenotype, overview Solanum lycopersicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GDP-D-mannose Solanum lycopersicum
-
 GDP-L-galactose
-
 ?

Organism

Organism UniProt Comment Textmining
Solanum lycopersicum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Solanum lycopersicum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-D-mannose
-
 Solanum lycopersicum GDP-L-galactose
-
 ?

Synonyms

Synonyms Comment Organism
GDP-D-mannose 3,5-epimerase
-
 Solanum lycopersicum
GME
-
 Solanum lycopersicum

General Information

General Information Comment Organism
metabolism GME is a central enzyme of the major ascorbate biosynthesis pathway in higher plants, it play a key role in the regulation of ascorbate biosynthesis in plants, adjusting the balance between ascorbate and cell-wall monosaccharide biosynthesis. GDP-D-mannose synthesis is the initial step in the pathway of ascorbate biosynthesis, and GDP-D-mannose is also a known precursor for the synthesis of D-mannose, L-fucose and L-galactose, and therefore for hemicelluloses such s the (galacto)glucomannans and for the pectin rhamnogalacturonan II Solanum lycopersicum