Application | Comment | Organism |
---|---|---|
diagnostics | GLCE upregulation plus expression pattern of a panel of six genes, discriminating morphologically different prostate cancer cell subtypes, is a potential marker of aggressive prostate cancer | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
enzyme GLCE is ectopically re-expressed in morphologically different LNCaP and PC3 prostate cancer cells, quantitative real-time PCR enzyme expression analysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O94923 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DU-145 cell | - |
Homo sapiens | - |
LNCaP cell | - |
Homo sapiens | - |
additional information | cDNA transcriptional microarray analysis of normal (PNT2) and prostate cancer (LNCaP, PC3, DU145) cells, overview | Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
PNT-2 cell | - |
Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
prostate gland cancer cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
D-glucuronyl C5-epimerase | - |
Homo sapiens |
Glce | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | D-glucuronyl C5-epimerase activity and presence of L-iduronic acid seem to be intrinsic properties of cells from prokaryotes to humans | Homo sapiens |
physiological function | D-glucuronyl C5-epimerase (GLCE) is one of the key heparan sulfate biosynthetic enzymes, responsible for the epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) in the heparan sulfate proteoglycans (HSPGs). IdoA presence increases a flexibility of HS chains and facilitates interaction of HSPGs with numerous extracellular and cell surface ligands including growth factors. The dynamic cooperation of proteoglycans, growth factor receptors, and integrins determines cell behavior, polarity, migration, differentiation, proliferation, and survival both in physiological and pathological conditions. D-glucuronyl C5-epimerase (GLCE) is involved in breast and lung carcinogenesis as a potential tumor suppressor gene, acting through inhibition of tumor angiogenesis and invasion/metastasis pathways. In prostate tumors, increased GLCE expression is associated with advanced disease, suggesting versatile effects of GLCE in different cancers, potential cancer-promoting effect of GLCE in prostate cancer and involvement of GLCE in carcinogenesis. GLCE up-regulation plus expression pattern of a panel of six genes, discriminating morphologically different prostate cancer cell sub-types, is suggested as a potential marker of aggressive prostate cancer | Homo sapiens |