Literature summary for 5.1.3.17 extracted from

Babu, P.; Victor, X.V.; Raman, K.; Kuberan, B.
A rapid, nonradioactive assay for measuring heparan sulfate C-5 epimerase activity using hydrogen/deuterium exchange-mass spectrometry (2015), Methods Mol. Biol., 1229, 209-219 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O94923	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	development and evaluation of a rapid, nonradioactive assay for measuring heparan sulfate C-5 epimerase activity using hydrogen/deuterium exchange-mass spectrometry, overview. The method involves the following steps: H/D exchange upon epimerization of the substrate with HS C5-epimerase, low-pH nitrous acid treatment of the substrate, the separation of low-pH nitrous acid-cleaved disaccharides using HPLC, and mass spectrometry analysis	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
C5-epi	-	Homo sapiens
heparan sulfate C-5 epimerase	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	heparin and heparan sulfate (HS) glycosaminoglycans have important roles in anticoagulation, human development, and human diseases. HS C5-epimerase, which catalyzes the reversible epimerization of GlcA to IdoA, is a crucial enzyme involved in the biosynthesis of heparin-related biomolecules	Homo sapiens

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Release 2023.1 (January 2023)