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Literature summary for 5.1.3.14 extracted from

  • Wang, Y.T.; Missiakas, D.; Schneewind, O.
    GneZ, a UDP-GlcNAc 2-epimerase, is required for S-layer assembly and vegetative growth of Bacillus anthracis (2014), J. Bacteriol., 196, 2969-2978 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.1.3.14

Cloned(Commentary)

Cloned (Comment) Organism
gene gneY, DNA and amino acid sequence determination and analysis, genetic structure, sequence comparisons Bacillus anthracis
gene gneYZ, DNA and amino acid sequence determination and analysis, genetic structure, sequence comparisons Bacillus anthracis

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine Bacillus anthracis
-
 UDP-N-acetyl-alpha-D-mannosamine
-
 r

Organism

Organism UniProt Comment Textmining
Bacillus anthracis Q81K32
-
-
Bacillus anthracis Q81X16
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine
-
 Bacillus anthracis UDP-N-acetyl-alpha-D-mannosamine
-
 r

Synonyms

Synonyms Comment Organism
bas5048
-
 Bacillus anthracis
bas5117
-
 Bacillus anthracis
GneY
-
 Bacillus anthracis
GneZ
-
 Bacillus anthracis
UDP-GlcNAc 2-epimerase
-
 Bacillus anthracis

General Information

General Information Comment Organism
evolution Bacillus anthracis gneY and gneZ encode nearly identical UDP-GlcNAc 2-epimerase enzymes that catalyze the reversible conversion of UDPGlcNAc and UDP-ManNAc Bacillus anthracis
physiological function GneZ, a UDP-GlcNAc 2-epimerase, is required for S-layer assembly and vegetative growth of Bacillus anthracis. Gene gneZ, but not gneY, is required for Bacillus anthracis vegetative growth, rod cell shape, S-layer assembly, and synthesis of pyruvylated secondary cell wall polysaccharide (SCWP). Nevertheless, inducible expression of gneY alleviates all the defects associated with the gneZ mutant. In contrast to vegetative growth, neither germination of Bacillus anthracis spores nor the formation of spores in mother cells require UDP-GlcNAc 2-epimerase activity. UDP-GlcNAc 2-epimerase enzymes have been shown to be required for the attachment of the phage lysin PlyG with the bacterial envelope and for bacterial growth. UDG-GlcNAc 2-epimerase activity, i.e., the expression of either gneY or gneZ, is not required for B. anthracis spore formation Bacillus anthracis