Literature summary for 5.1.3.14 extracted from

Moeller, H.; Boehrsch, V.; Lucka, L.; Hackenberger, C.P.; Hinderlich, S.
Efficient metabolic oligosaccharide engineering of glycoproteins by UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) knock-down (2011), Mol. Biosyst., 7, 2245-2251.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
GNE	-	Homo sapiens
UDP-GlcNAc 2-epimerase/ManNAc kinase	-	Homo sapiens
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	stable knock-down of GNE dramatically increases incorporation of N-acetylmannosamine analogues into glycoproteins of HEK-293 cells	Homo sapiens
metabolism	GNE is the key enzyme in the sialic acid biosynthetic pathway	Homo sapiens

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Release 2023.1 (January 2023)