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Literature summary for 5.1.3.14 extracted from

  • Castilho, A.; Pabst, M.; Leonard, R.; Veit, C.; Altmann, F.; Mach, L.; Gloessl, J.; Strasser, R.; Steinkellner, H.
    Construction of a functional CMP-sialic acid biosynthesis pathway in Arabidopsis (2008), Plant Physiol., 147, 331-339.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.1.3.14

Application

Application Comment Organism
synthesis transgenic Arabidopsis thaliana plants expressing three key enzymes of the mammalian Neu5Ac biosynthesis pathway: UDPN-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, N-acetylneuraminic acid phosphate synthase, and CMP-Nacetylneuraminic acid synthetase. Simultaneous expression of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase and N-acetylneuraminic acid phosphate synthase results in the generation of significant Neu5Ac amounts of 1275 nmol per g fresh weight in leaves, which can be further converted to cytidine monophospho-N-acetylneuraminic acid by coexpression of CMP-N-acetylneuraminic acid synthetase Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression in Arabidopsis thaliana Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information transgenic Arabidopsis thaliana plants expressing three key enzymes of the mammalian Neu5Ac biosynthesis pathway: UDPN-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, N-acetylneuraminic acid phosphate synthase, and CMP-Nacetylneuraminic acid synthetase. Simultaneous expression of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase and N-acetylneuraminic acid phosphate synthase results in the generation of significant Neu5Ac amounts of 1275 nmol per g fresh weight in leaves, which can be further converted to cytidine monophospho-N-acetylneuraminic acid by coexpression of CMP-N-acetylneuraminic acid synthetase Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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