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Literature summary for 5.1.3.13 extracted from

  • Nguyen, V.; Flanagan, B.; Mikkelsen, D.; Ramirez, S.; Rivas, L.; Gidley, M.; Dykes, G.
    Spontaneous mutation results in lower cellulose production by a Gluconacetobacter xylinus strain from Kombucha (2010), Carbohydr. Polym., 80, 338-344.
No PubMed abstract available
Search for more literature for 5.1.3.13

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dTDP-4-dehydro-6-deoxy-D-glucose Komagataeibacter xylinus the enzyme is involved in the dTDP-rhamnose synthesis pathway which consists of three steps: (i) the synthesis of dTDP-4-keto-6-deoxy-D-glucose from glucose 1-phosphate and dTDP, (ii) the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-4-keto-L-rhamnose by dTDP-4-dehydrorhamnose 3,5-epimerase and (iii) the reduction of dTDP-4-keto-L-rhamnose to dTDP-L-rhamnose. The mutant K3 strain, with a spontaneous mutation that results in lower cellulose production, shows deoxythymidine diphosphate-4-dehydrorhamnose 3,5-epimerase activity, while the wild-type does not, determined by 2D-gel electrophoresis. It is possible that in the wild-type, transcription of the gene responsible for the expression of dTDP-4-dehydrorhamnose 3,5-epimerase is repressed by a transcription factor, and that a mutation in the gene encoding the transcription factor has rendered it non-functional dTDP-4-dehydro-L-rhamnose
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 ?

Organism

Organism UniProt Comment Textmining
Komagataeibacter xylinus
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 mutant strain K3, isolated from Kombucha, Kombu Australia, Springwood, Queensland, Australia
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dTDP-4-dehydro-6-deoxy-D-glucose
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 Komagataeibacter xylinus dTDP-4-dehydro-L-rhamnose
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 ?
dTDP-4-dehydro-6-deoxy-D-glucose the enzyme is involved in the dTDP-rhamnose synthesis pathway which consists of three steps: (i) the synthesis of dTDP-4-keto-6-deoxy-D-glucose from glucose 1-phosphate and dTDP, (ii) the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-4-keto-L-rhamnose by dTDP-4-dehydrorhamnose 3,5-epimerase and (iii) the reduction of dTDP-4-keto-L-rhamnose to dTDP-L-rhamnose. The mutant K3 strain, with a spontaneous mutation that results in lower cellulose production, shows deoxythymidine diphosphate-4-dehydrorhamnose 3,5-epimerase activity, while the wild-type does not, determined by 2D-gel electrophoresis. It is possible that in the wild-type, transcription of the gene responsible for the expression of dTDP-4-dehydrorhamnose 3,5-epimerase is repressed by a transcription factor, and that a mutation in the gene encoding the transcription factor has rendered it non-functional Komagataeibacter xylinus dTDP-4-dehydro-L-rhamnose
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 ?

Synonyms

Synonyms Comment Organism
deoxythymidine diphosphate-4-dehydrorhamnose 3,5-epimerase
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 Komagataeibacter xylinus
dTDP-4-dehydrorhamnose 3,5-epimerase
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 Komagataeibacter xylinus

General Information

General Information Comment Organism
metabolism dTDP-4-dehydrorhamnose 3,5-epimerase is an enzyme which may be associated with the cellulose synthesis-reducing effect of the mutation in strain K3 Komagataeibacter xylinus