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Literature summary for 5.1.2.1 extracted from

  • Desguin, B.; Zhang, T.; Soumillion, P.; Hols, P.; Hu, J.; Hausinger, R.
    A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase (2015), Science, 349, 66-69 .
    View publication on PubMed
Search for more literature for 5.1.2.1

Activating Compound

Activating Compound Comment Organism Structure
additional information nickel-binding site structure and the role of three accessory proteins required for its activation, overview Lactiplantibacillus plantarum

Metals/Ions

Metals/Ions Comment Organism Structure
Ni2+ absolutely required. Lactobacillus plantarum possesses an organometallic nickel-containing prosthetic group. A nicotinic acid mononucleotide derivative is tethered to Lys184 and forms a tridentate pincer complex that coordinates nickel through one metal-carbon and two metal-sulfur bonds, with His200 as another ligand. Nickel-binding site structure and the role of three accessory proteins required for its activation, overview Lactiplantibacillus plantarum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-lactate Lactiplantibacillus plantarum
-
 (R)-lactate
-
 r
(S)-lactate Lactiplantibacillus plantarum ATCC BAA-793 / NCIMB 8826 / WCFS1
-
 (R)-lactate
-
 r

Organism

Organism UniProt Comment Textmining
Lactiplantibacillus plantarum F9USS9
-
-
Lactiplantibacillus plantarum ATCC BAA-793 / NCIMB 8826 / WCFS1 F9USS9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-lactate
-
 Lactiplantibacillus plantarum (R)-lactate
-
 r
(S)-lactate
-
 Lactiplantibacillus plantarum ATCC BAA-793 / NCIMB 8826 / WCFS1 (R)-lactate
-
 r

Synonyms

Synonyms Comment Organism
LARa
-
 Lactiplantibacillus plantarum

General Information

General Information Comment Organism
additional information the wide distribution of the accessory proteins without Lar Lactiplantibacillus plantarum
physiological function lactic acid racemization is involved in lactate metabolism and cell wall assembly of many microorganisms Lactiplantibacillus plantarum