BRENDA - Enzyme Database
show all sequences of 5.1.1.4

Biochemical characterization of proline racemases from the human protozoan parasite Trypanosoma cruzi and definition of putative protein signatures

Chamond, N.; Gregoire, C.; Coatnoan, N.; Rougeot, C.; Freitas-Junior, L.H.; da Silveira, J.F.; Degrave, W.M.; Minoprio, P.; J. Biol. Chem. 278, 15484-15494 (2003)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
potential of the enzyme as a critical target for drug development against Chaga‘s disease. The enzyme is absent in mammalian host, suggesting that inhibition of proline racemase may have therapeutic potential; potential of the enzyme as a critical target for drug development against Chagas‘ disease. The enzyme is absent in mammalian host, suggesting that inhibition of proline racemase may have therapeutic potential
Trypanosoma cruzi
Cloned(Commentary)
Cloned (Commentary)
Organism
expression in Escherichia coli
Trypanosoma cruzi
Inhibitors
Inhibitors
Commentary
Organism
Structure
pyrrole-2-carboxylic acid
-
Trypanosoma cruzi
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
29
-
L-proline
pH 6.0, 37°C
Trypanosoma cruzi
75
-
L-proline
pH 6.0, 37°C
Trypanosoma cruzi
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
extracellular
membrane-bound and secreted forms of enzyme are present upon differentiation of the parasite into non-dividing infective forms
Trypanosoma cruzi
-
-
intracellular
in replicative non-infective forms of Trypanosoma cruzi
Trypanosoma cruzi
5622
-
membrane
membrane-bound and secreted forms of enzyme are present upon differentiation of the parasite into non-dividing infective forms
Trypanosoma cruzi
16020
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
40100
-
2 * 40100, TcPRACB, SDS-PAGE
Trypanosoma cruzi
45800
-
2 * 45800, TcPRACA, SDS-PAGE
Trypanosoma cruzi
80000
-
TCPRACA, gel filtration, non-denaturing PAGE
Trypanosoma cruzi
Organism
Organism
UniProt
Commentary
Textmining
Trypanosoma cruzi
Q4DA80
-
-
Trypanosoma cruzi
Q868H8
-
-
Storage Stability
Storage Stability
Organism
-20°C, 50% glycerol or diluted in sodium acetate buffer, pH 6.0, activity is impaired
Trypanosoma cruzi
-20°C, 50% glycerol or diluted in sodium acetate buffer, pH 6.0, stable
Trypanosoma cruzi
-20°C, as ammonium sulfate precipitate, stable
Trypanosoma cruzi
23°C, 0.5 M imidazole buffer, pH 8.0, 10 days, TcPRACA loses 84% of its activity
Trypanosoma cruzi
23°C, 0.5 M imidazole buffer, pH 8.0, 10 days, TcPRACB is stable, TcPRACA loses 84% of its activity
Trypanosoma cruzi
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
L-proline
-
652377
Trypanosoma cruzi
D-proline
-
652377
Trypanosoma cruzi
?
L-proline
-
652377
Trypanosoma cruzi
D-proline
-
-
-
-
additional information
TcPRACB: no reaction with L-hydroxyproline
652377
Trypanosoma cruzi
?
-
652377
Trypanosoma cruzi
?
Subunits
Subunits
Commentary
Organism
dimer
2 * 40100, TcPRACB, SDS-PAGE; 2 * 45800, TcPRACA, SDS-PAGE
Trypanosoma cruzi
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
-
Trypanosoma cruzi
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
80
-
5 min, activity is abolished
Trypanosoma cruzi
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
4.5
8.5
-
Trypanosoma cruzi
5.5
7
-
Trypanosoma cruzi
Cofactor
Cofactor
Commentary
Organism
Structure
additional information
TcPRACB is a cofactor-independent racemase
Trypanosoma cruzi
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.0036
-
pyrrole-2-carboxylic acid
pH 6.0, 37°C, TcPRACB
Trypanosoma cruzi
0.0057
-
pyrrole-2-carboxylic acid
pH 6.0, 37°C, TcPRACA
Trypanosoma cruzi
Application (protein specific)
Application
Commentary
Organism
medicine
potential of the enzyme as a critical target for drug development against Chaga‘s disease. The enzyme is absent in mammalian host, suggesting that inhibition of proline racemase may have therapeutic potential; potential of the enzyme as a critical target for drug development against Chagas‘ disease. The enzyme is absent in mammalian host, suggesting that inhibition of proline racemase may have therapeutic potential
Trypanosoma cruzi
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Escherichia coli
Trypanosoma cruzi
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
additional information
TcPRACB is a cofactor-independent racemase
Trypanosoma cruzi
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
pyrrole-2-carboxylic acid
-
Trypanosoma cruzi
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.0036
-
pyrrole-2-carboxylic acid
pH 6.0, 37°C, TcPRACB
Trypanosoma cruzi
0.0057
-
pyrrole-2-carboxylic acid
pH 6.0, 37°C, TcPRACA
Trypanosoma cruzi
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
29
-
L-proline
pH 6.0, 37°C
Trypanosoma cruzi
75
-
L-proline
pH 6.0, 37°C
Trypanosoma cruzi
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
extracellular
membrane-bound and secreted forms of enzyme are present upon differentiation of the parasite into non-dividing infective forms
Trypanosoma cruzi
-
-
intracellular
in replicative non-infective forms of Trypanosoma cruzi
Trypanosoma cruzi
5622
-
membrane
membrane-bound and secreted forms of enzyme are present upon differentiation of the parasite into non-dividing infective forms
Trypanosoma cruzi
16020
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
40100
-
2 * 40100, TcPRACB, SDS-PAGE
Trypanosoma cruzi
45800
-
2 * 45800, TcPRACA, SDS-PAGE
Trypanosoma cruzi
80000
-
TCPRACA, gel filtration, non-denaturing PAGE
Trypanosoma cruzi
Storage Stability (protein specific)
Storage Stability
Organism
-20°C, 50% glycerol or diluted in sodium acetate buffer, pH 6.0, activity is impaired
Trypanosoma cruzi
-20°C, 50% glycerol or diluted in sodium acetate buffer, pH 6.0, stable
Trypanosoma cruzi
-20°C, as ammonium sulfate precipitate, stable
Trypanosoma cruzi
23°C, 0.5 M imidazole buffer, pH 8.0, 10 days, TcPRACA loses 84% of its activity
Trypanosoma cruzi
23°C, 0.5 M imidazole buffer, pH 8.0, 10 days, TcPRACB is stable, TcPRACA loses 84% of its activity
Trypanosoma cruzi
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
L-proline
-
652377
Trypanosoma cruzi
D-proline
-
652377
Trypanosoma cruzi
?
L-proline
-
652377
Trypanosoma cruzi
D-proline
-
-
-
-
additional information
TcPRACB: no reaction with L-hydroxyproline
652377
Trypanosoma cruzi
?
-
652377
Trypanosoma cruzi
?
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
2 * 40100, TcPRACB, SDS-PAGE; 2 * 45800, TcPRACA, SDS-PAGE
Trypanosoma cruzi
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
-
Trypanosoma cruzi
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
80
-
5 min, activity is abolished
Trypanosoma cruzi
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
4.5
8.5
-
Trypanosoma cruzi
5.5
7
-
Trypanosoma cruzi
Other publictions for EC 5.1.1.4
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
730678
Watanabe
Identification and characteriz ...
Clostridioides difficile, Ferroplasma acidarmanus, Haloarcula japonica, Haloarcula japonica DSM 6131, Thermococcus litoralis, Thermococcus litoralis DSM 5473
PLoS One
10
e0120349
2015
-
-
4
-
2
-
4
15
-
-
8
-
-
12
-
-
4
-
-
-
-
-
12
4
5
8
-
-
15
4
-
-
-
-
-
4
-
-
4
-
-
2
-
4
4
-
15
-
-
8
-
-
-
-
4
-
-
-
-
12
4
8
-
-
15
4
-
-
-
-
-
-
-
15
15
748829
Caballero
Phylogenetic and syntenic dat ...
no activity in Trypanosoma brucei, no activity in Trypanosoma congolense, Trypanosoma conorhini, Trypanosoma conorhini TCC025, Trypanosoma cruzi, Trypanosoma cruzi CL Brener, Trypanosoma cruzi marinkellei, Trypanosoma cruzi marinkellei TCC344, Trypanosoma dionisii, Trypanosoma dionisii TCC211, Trypanosoma erneyi, Trypanosoma erneyi TCC1946, Trypanosoma grayi, Trypanosoma grayi ANR4, Trypanosoma lewisi, Trypanosoma lewisi TCC034, Trypanosoma rangeli, Trypanosoma serpentis, Trypanosoma serpentis TCC1052, Trypanosoma sp., Trypanosoma sp. TCC1825 / RCF-2014, Trypanosoma sp. TCC339, Trypanosoma sp. TCC878, Trypanosoma sp. TCC878 RCF-2014, Trypanosoma vivax, Trypanosoma vivax Y486
Parasit. Vectors
8
222
2015
-
-
13
-
-
-
-
-
-
-
-
-
-
47
-
-
-
-
-
-
-
-
-
-
37
-
-
-
-
-
-
-
-
-
-
-
-
-
14
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
13
14
-
-
-
727156
Harty
Inhibition of serine and proli ...
Acetoanaerobium sticklandii
Bioorg. Med. Chem. Lett.
24
390-393
2014
-
-
1
-
-
-
4
1
-
-
-
1
-
3
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
1
-
2
-
-
1
1
-
-
-
2
4
1
1
-
-
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
727265
Wu
The Clostridium difficile prol ...
Clostridioides difficile
Can. J. Microbiol.
60
251-254
2014
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
749144
Fikru
A proline racemase based PCR ...
Trypanosoma vivax, Trypanosoma vivax ILRAD 1392
PLoS ONE
9
e84819
2014
-
1
-
-
1
-
-
-
-
-
-
-
-
15
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
728600
Berneman
Combined approaches for drug d ...
Trypanosoma cruzi
PLoS ONE
8
e60955
2013
-
-
1
-
-
-
9
-
-
-
-
1
-
4
-
-
1
-
-
-
-
-
1
-
1
1
-
-
-
1
-
-
-
6
-
-
-
-
1
-
-
-
-
-
9
6
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
715163
Bryan
Genetic immunization converts ...
Trypanosoma cruzi, Trypanosoma cruzi Y
Infect. Immun.
78
810-822
2010
-
-
1
-
-
-
-
-
-
-
1
-
-
12
-
-
1
-
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
704196
Rubinstein
Catalyzing racemizations in th ...
Trypanosoma cruzi
J. Am. Chem. Soc.
131
8513-8521
2009
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
704292
Fonknechten
A conserved gene cluster rules ...
Acetoanaerobium sticklandii
J. Bacteriol.
191
3162-3167
2009
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
705499
Coutinho
Inhibition of Trypanosoma cruz ...
Trypanosoma cruzi
Mem. Inst. Oswaldo Cruz
104
1055-1062
2009
-
-
-
-
-
-
1
-
1
-
-
1
-
3
-
-
-
-
-
3
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
2
1
1
2
-
-
705500
Coatnoan
Proline racemases: Insights in ...
Trypanosoma cruzi
Mem. Inst. Oswaldo Cruz
104
295-300
2009
-
-
1
-
-
-
-
-
-
-
-
2
-
3
-
-
-
-
-
2
-
-
2
1
6
-
-
-
-
-
-
-
-
-
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-
-
-
2
-
-
-
-
-
-
-
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2
-
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-
-
4
-
-
2
2
-
-
-
-
-
-
-
-
1
1
2
2
-
-
705596
Chamond
Proline racemases are conserve ...
Trypanosoma vivax
Mol. Biochem. Parasitol.
165
170-179
2009
-
1
1
-
-
-
1
2
-
-
1
1
-
7
-
-
1
-
-
3
-
-
1
-
3
1
-
-
-
1
-
-
-
1
-
-
-
1
1
-
-
-
-
-
1
1
2
-
-
1
1
-
-
-
1
-
3
-
-
1
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
675621
Stenta
The Catalytic Activity of Prol ...
Trypanosoma cruzi
J. Phys. Chem. B
112
1057-1059
2008
-
-
-
-
-
-
-
-
-
-
-
-
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3
-
-
-
1
-
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-
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2
-
1
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-
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-
-
-
-
-
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-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676749
Goytia
Molecular and structural discr ...
Clostridioides difficile, Clostridioides difficile VPI10463
PLoS ONE
2
e885
2007
-
-
1
-
-
-
1
2
-
-
-
-
-
7
-
-
-
-
-
-
-
-
2
-
2
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
676832
Buschiazzo
Crystal structure, catalytic m ...
Trypanosoma cruzi
Proc. Natl. Acad. Sci. USA
103
1705-1710
2006
-
-
1
1
2
-
1
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
1
1
2
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
2
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
662908
Chamond
Trypanosoma cruzi proline race ...
Trypanosoma cruzi
Mol. Microbiol.
58
46-60
2005
-
-
-
-
-
-
-
-
2
-
-
1
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2
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Fisher
Energetics of proline racemase ...
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Biochemistry
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Fisher
Energetics of proline racemase ...
Acetoanaerobium sticklandii
Biochemistry
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Belasco
Energetics of proline racemase ...
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Biochemistry
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Fisher
Energetics of proline racemase ...
Acetoanaerobium sticklandii
Biochemistry
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1986
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Belasco
Energetics of proline racemase ...
Acetoanaerobium sticklandii
Biochemistry
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2558-2564
1986
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Albery
Energetics and mechanism of pr ...
Acetoanaerobium sticklandii
Biochemistry
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2572-2577
1986
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2131
Belasco
Energetics of proline racemase ...
Acetoanaerobium sticklandii
Biochemistry
25
2552-2558
1986
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Rudnick
Reaction mechanism and structu ...
Acetoanaerobium sticklandii
Biochemistry
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4515-4522
1975
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3
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2123
Keenan
The inhibition of proline race ...
Acetoanaerobium sticklandii
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1974
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2122
Cardinale
Purification and mechanism of ...
Acetoanaerobium sticklandii
Biochemistry
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1968
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Stadtman
Studies on the enzymic reducti ...
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