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Literature summary for 5.1.1.3 extracted from
- Distribution of glutamate racemase in lactic acid bacteria and further characterization of the enzyme from Pediococcus pentosaceus (1988), Agric. Biol. Chem., 52, 3099-3104.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Nitro-5-thiocyanobenzoate | complete inactivation at 0.1 mM | Pediococcus pentosaceus |  |
| iodoacetamide | - |
Pediococcus pentosaceus | |
| L-alpha-aminohexanedioate | - |
Pediococcus pentosaceus | |
| Thiol-blocking reagents | - |
Pediococcus pentosaceus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 10 | - |
L-Glu | - |
Pediococcus pentosaceus | |
| 14 | - |
D-Glu | - |
Pediococcus pentosaceus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Glu | Lactic acid bacteria | the biosynthesis of D-Glu, one of the essential components of bacterial cell-wall peptidoglycan, is catalyzed by glutamate racemase | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lactic acid bacteria | - |
enzyme occurs exclusively in lactic acid bacteria | - |
| Lacticaseibacillus casei | - |
subsp. casei and subsp. rhamnosus | - |
| Lactiplantibacillus plantarum | - |
- |
- |
| Lactobacillus sp. | - |
- |
- |
| Leuconostoc lactis | - |
- |
- |
| Limosilactobacillus fermentum | - |
- |
- |
| no activity in Clostridium sp. | - |
- |
- |
| Pediococcus acidilactici | - |
- |
- |
| Pediococcus pentosaceus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Pediococcus pentosaceus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| L-glutamate = D-glutamate | initial step is the proton abstraction from the substrate alpha-carbon atom, which is mediated by an amino acid residue in the enzyme protein | Pediococcus pentosaceus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Glu | - |
Lactiplantibacillus plantarum | L-Glu | - |
? | |
| D-Glu | - |
Lacticaseibacillus casei | L-Glu | - |
? | |
| D-Glu | - |
Limosilactobacillus fermentum | L-Glu | - |
? | |
| D-Glu | - |
Pediococcus pentosaceus | L-Glu | - |
? | |
| D-Glu | - |
Lactobacillus sp. | L-Glu | - |
? | |
| D-Glu | - |
Lactic acid bacteria | L-Glu | - |
? | |
| D-Glu | - |
Pediococcus acidilactici | L-Glu | - |
? | |
| D-Glu | - |
Leuconostoc lactis | L-Glu | - |
? | |
| L-Glu | the biosynthesis of D-Glu, one of the essential components of bacterial cell-wall peptidoglycan, is catalyzed by glutamate racemase | Lactic acid bacteria | ? | - |
? | |
| L-Homocysteinesulfinate | slightly serves as substrate | Pediococcus pentosaceus | D-Homocysteinesulfinate | - |
? | |
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