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Literature summary for 5.1.1.23 extracted from

  • Ogasawara, Y.; Dairi, T.
    Peptide epimerization machineries found in microorganisms (2018), Front. Microbiol., 9, 156 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene murL, shotgun cloning experiment with DGlu auxotrophic Escherichia coli strain WM335 Xanthomonas oryzae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Xanthomonas oryzae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + UDP-MurNAc-L-Ala-L-Glu Xanthomonas oryzae
-
AMP + diphosphate + UDP-MurNAc-L-Ala-D-Glu
-
ir
ATP + UDP-MurNAc-L-Ala-L-Glu Xanthomonas oryzae MAFF311018
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AMP + diphosphate + UDP-MurNAc-L-Ala-D-Glu
-
ir

Organism

Organism UniProt Comment Textmining
Xanthomonas oryzae Q5H398
-
-
Xanthomonas oryzae MAFF311018 Q5H398
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + UDP-MurNAc-L-Ala-L-Glu
-
Xanthomonas oryzae AMP + diphosphate + UDP-MurNAc-L-Ala-D-Glu
-
ir
ATP + UDP-MurNAc-L-Ala-L-Glu the terminal L-Glu of the substrate is converted into D-Glu Xanthomonas oryzae AMP + diphosphate + UDP-MurNAc-L-Ala-D-Glu
-
ir
ATP + UDP-MurNAc-L-Ala-L-Glu
-
Xanthomonas oryzae MAFF311018 AMP + diphosphate + UDP-MurNAc-L-Ala-D-Glu
-
ir
ATP + UDP-MurNAc-L-Ala-L-Glu the terminal L-Glu of the substrate is converted into D-Glu Xanthomonas oryzae MAFF311018 AMP + diphosphate + UDP-MurNAc-L-Ala-D-Glu
-
ir
additional information XOO_1319 is a distinct type of glycopeptidyl-glutamate epimerase and is designated XOO_1319 as UDP-MurNAc-LAla-L-Glu epimerase, MurL. It shows no activity in the reverse reaction with UDP-MurNAc-L-Ala-D-Glu. MurL requires ATP and Mg2+ for its activity and AMP is generated as a side product, suggesting that the substrate is activated by adenylation Xanthomonas oryzae ?
-
?
additional information XOO_1319 is a distinct type of glycopeptidyl-glutamate epimerase and is designated XOO_1319 as UDP-MurNAc-LAla-L-Glu epimerase, MurL. It shows no activity in the reverse reaction with UDP-MurNAc-L-Ala-D-Glu. MurL requires ATP and Mg2+ for its activity and AMP is generated as a side product, suggesting that the substrate is activated by adenylation Xanthomonas oryzae MAFF311018 ?
-
?

Synonyms

Synonyms Comment Organism
MurL
-
Xanthomonas oryzae
UDP-MurNAc-L-Ala-L-Glu epimerase
-
Xanthomonas oryzae
XOO_1319
-
Xanthomonas oryzae

Cofactor

Cofactor Comment Organism Structure
ATP
-
Xanthomonas oryzae

General Information

General Information Comment Organism
metabolism the enzyme is involved in the biosynthesis of UDP-MurNAc-pentapeptide, pathway overview Xanthomonas oryzae
additional information MurL lacks known conserved domains and cofactor binding domains Xanthomonas oryzae