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Literature summary for 5.1.1.19 extracted from
- Characterization of DcsC, a PLP-independent racemase involved in the biosynthesis of D-cycloserine (2012), Org. Biomol. Chem., 10, 2248-2254.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Streptomyces lavendulae subsp. lavendulae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-[[(carbamoylamino)oxy]methyl]oxiran-2-carboxylic acid | irreversible inhibition | Streptomyces lavendulae subsp. lavendulae |  |
| Hg2+ | 0.01 mM, complete inhibition | Streptomyces lavendulae subsp. lavendulae | |
| iodoacetamide | complete inhibition | Streptomyces lavendulae subsp. lavendulae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 17 | - |
O-ureido-D-serine | pH 7.9, 30°C | Streptomyces lavendulae subsp. lavendulae | |
| 110 | - |
O-ureido-L-serine | pH 7.9, 30°C | Streptomyces lavendulae subsp. lavendulae | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 31205 | - |
x * 31205, ESI-TOF mass spectrometry | Streptomyces lavendulae subsp. lavendulae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| O-ureido-L-serine | Streptomyces lavendulae subsp. lavendulae | the enzyme is involved in the biosynthesis of the antibiotic D-cycloserine | O-ureido-D-serine | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces lavendulae subsp. lavendulae | D2Z026 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Streptomyces lavendulae subsp. lavendulae |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| O-ureido-L-serine = O-ureido-D-serine | the enzyme employs a two-base mechanism, with a thiolatethiol pair in the active site | Streptomyces lavendulae subsp. lavendulae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| O-ureido-L-serine | the enzyme is involved in the biosynthesis of the antibiotic D-cycloserine | Streptomyces lavendulae subsp. lavendulae | O-ureido-D-serine | - |
r | |
| O-ureido-L-serine | - |
Streptomyces lavendulae subsp. lavendulae | O-ureido-D-serine | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 31205, ESI-TOF mass spectrometry | Streptomyces lavendulae subsp. lavendulae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DcsC | - |
Streptomyces lavendulae subsp. lavendulae |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 29 | - |
O-ureido-D-serine | pH 7.9, 30°C | Streptomyces lavendulae subsp. lavendulae | |
| 158 | - |
O-ureido-L-serine | pH 7.9, 30°C | Streptomyces lavendulae subsp. lavendulae | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
- |
Streptomyces lavendulae subsp. lavendulae |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.44 | - |
O-ureido-L-serine | pH 7.9, 30°C | Streptomyces lavendulae subsp. lavendulae | |
| 1.71 | - |
O-ureido-D-serine | pH 7.9, 30°C | Streptomyces lavendulae subsp. lavendulae | |
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