Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.1.1.18 extracted from

  • Mori, H.; Wada, R.; Li, J.; Ishimoto, T.; Mizuguchi, M.; Obita, T.; Gouda, H.; Hirono, S.; Toyooka, N.
    In silico and pharmacological screenings identify novel serine racemase inhibitors (2014), Bioorg. Med. Chem. Lett., 24, 3732-3735 .
    View publication on PubMed
Search for more literature for 5.1.1.18

Inhibitors

Inhibitors Comment Organism Structure
malonate
-
 Homo sapiens
additional information in silico and pharmacological inhibitor screenings, enzyme homology modeling, four active sites of hSR (two malonate-bound and two ligand-free forms) are used in this protein structure-based virtual screening, ligand docking Homo sapiens
N-(4-bromophenyl)-N2-[(4-fluorophenoxy)acetyl]glycinamide
-
 Homo sapiens
N2-[(4-bromophenoxy)acetyl]-N-(2,6-difluorophenyl)glycinamide
-
 Homo sapiens
N2-[(4-bromophenoxy)acetyl]-N-(4-iodophenyl)glycinamide
-
 Homo sapiens
N2-[(4-fluorophenoxy)acetyl]-N-(4-iodophenyl)glycinamide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-serine Homo sapiens
-
 D-serine
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9GZT4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine
-
 Homo sapiens D-serine
-
 r

Synonyms

Synonyms Comment Organism
hSR
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.31
-
 pH and temperature not specified in the publication Homo sapiens malonate

General Information

General Information Comment Organism
additional information homology modeling of the ligand-free form of the human enzyme, in which the X-ray crystal structure of ligand-free rat enzyme, PDB ID 3HMK, is used as a template Homo sapiens