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Literature summary for 5.1.1.18 extracted from

  • Inoue, R.; Yoshihisa, Y.; Tojo, Y.; Okamura, C.; Yoshida, Y.; Kishimoto, J.; Luan, X.; Watanabe, M.; Mizuguchi, M.; Nabeshima, Y.; Hamase, K.; Matsunaga, K.; Shimizu, T.; Mori, H.
    Localization of serine racemase and its role in the skin (2014), J. Invest. Dermatol., 134, 1618-1626.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression of GST-tagged fusion protein containing amino acid residue 150-190 of the mouse enzyme, expression of His-tagged enzyme in Cavia porcellus and Oryctolagus cuniculus, quantitative real-time PCR enzyme expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of enzyme knockout mutant mice, phenotypes, overview Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Mus musculus C57BL/6
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Source Tissue

Source Tissue Comment Organism Textmining
central nervous system
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 Mus musculus
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keratinocyte epidermal Mus musculus
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skin localization of the enzme protein in the granular and cornified layer of the epidermis Mus musculus
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General Information

General Information Comment Organism
malfunction enzyme knockout mice show increased expression of involucrin and keratin 10 in the epidermis compared to wild-type mice Mus musculus
physiological function D-serine is an endogenous coagonist of the N-methyl-D-aspartate-type glutamate receptor in the central nervous system and its synthesis is catalyzed by serine racemase Mus musculus