Literature summary for 5.1.1.18 extracted from

Mustafa, A.K.; Ahmad, A.S.; Zeynalov, E.; Gazi, S.K.; Sikka, G.; Ehmsen, J.T.; Barrow, R.K.; Coyle, J.T.; Snyder, S.H.; Dore, S.
Serine racemase deletion protects against cerebral ischemia and excitotoxicity (2010), J. Neurosci., 30, 1413-1416.

Search for more literature for 5.1.1.18

Protein Variants

Protein Variants	Comment	Organism
additional information	targeted deletion of the enzyme lead to markedly diminished nitric oxide formation and neurotoxicity in the brain, NO formation and nitrosylation of NO targets are reduced. Knockout mice show highly diminished infarct volume following middle cerebral artery occlusion in several regions of the brains, while the number and sensitivity of the NMDA receptors are increased, phenotype, overview	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-serine	Mus musculus	-	D-serine	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-serine	-	Mus musculus	D-serine	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)