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Literature summary for 5.1.1.18 extracted from

  • Labrie, V.; Fukumura, R.; Rastogi, A.; Fick, L.J.; Wang, W.; Boutros, P.C.; Kennedy, J.L.; Semeralul, M.O.; Lee, F.H.; Baker, G.B.; Belsham, D.D.; Barger, S.W.; Gondo, Y.; Wong, A.H.; Roder, J.C.
    Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model (2009), Hum. Mol. Genet., 18, 3227-3243.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.1.1.18

Protein Variants

Protein Variants Comment Organism
additional information generation of mice with an ENU-induced mutation, SrrY269stop, that results in a complete loss of Srr activity and dramatically reduced D-serine levels. Mutant mice display behaviors relevant to schizophrenia, including impairments in prepulse inhibition, sociability and spatial discrimination. Behavioral deficits are exacerbated by an NMDAR antagonist and ameliorated by D-serine or the atypical antipsychotic clozapine. Expression profiling reveals that the Srr mutation influences several genes that are linked to schizophrenia and cognitive ability, expression pattern of the enzyme in mutant brain tissues, detailed phenotype, overview Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29000
-
 x * 29000, truncated mutant enzyme, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-serine Mus musculus
-
 D-serine D-serine is an important modulator of the N-methyl-D-aspartate receptor function ?
L-serine Homo sapiens
-
 D-serine D-serine is an important modulator of the N-methyl-D-aspartate receptor function ?
L-serine Mus musculus C57BL/6JJcl
-
 D-serine D-serine is an important modulator of the N-methyl-D-aspartate receptor function ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 different SRR genetic variants
-
Mus musculus
-
 and strain DBA/2JJcl
-
Mus musculus C57BL/6JJcl
-
 and strain DBA/2JJcl
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
brain expression pattern of the enzyme in brain tissues Mus musculus
-
cerebellum
-
 Mus musculus
-
frontal cortex
-
 Mus musculus
-
frontal lobe
-
 Mus musculus
-
hippocampus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine
-
 Mus musculus D-serine
-
 ?
L-serine
-
 Homo sapiens D-serine
-
 ?
L-serine
-
 Mus musculus D-serine D-serine is an important modulator of the N-methyl-D-aspartate receptor function ?
L-serine
-
 Homo sapiens D-serine D-serine is an important modulator of the N-methyl-D-aspartate receptor function ?
L-serine
-
 Mus musculus C57BL/6JJcl D-serine
-
 ?
L-serine
-
 Mus musculus C57BL/6JJcl D-serine D-serine is an important modulator of the N-methyl-D-aspartate receptor function ?

Subunits

Subunits Comment Organism
? x * 29000, truncated mutant enzyme, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
SRR
-
 Mus musculus
SRR
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction serine racemase is associated with schizophrenia susceptibility in a mouse model, abnormal N-methyl-D-aspartate receptor function is implicated in the pathophysiology of schizophrenia Mus musculus
malfunction serine racemase is associated with schizophrenia susceptibility in humans, abnormal N-methyl-D-aspartate receptor function is implicated in the pathophysiology of schizophrenia Homo sapiens