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Literature summary for 5.1.1.17 extracted from
- Deacetylcephalosporin C production in Penicillium chrysogenum by expression of the isopenicillin N epimerization, ring expansion, and acetylation genes (2007), Chem. Biol., 14, 329-339.
Application
| Application | Comment | Organism |
|---|---|---|
| biotechnology | The results indicate that Penecillium chrysogenum can be used as heterologous host for the production of deacetylcephalosporin C | Acremonium chrysogenum |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| Penecillium chrysogenum strains are constructed expressing cefD1 (isopenecillin N-CoA synthetase), cefD2 (isopenecillin N-CoA epimerase), cefEF (deacetylcephalosporin-actyltransferase), and cefG (deacetylcephalosporin C synthetase) genes cloned from Acremonium chrysogenum. HPLC analysis of cell extracts show that transformant TA64, TA71, and TA98 accumulate intracellularly deacetylcephalosporin C and, in the last strain (TA98), also cephalosporin C. | Acremonium chrysogenum |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Acremonium chrysogenum | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| isopenicillin N | - |
Acremonium chrysogenum | penicillin N | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| isopenecillin N-CoA epimerase | - |
Acremonium chrysogenum |
| isopenicillin N epimerase | - |
Acremonium chrysogenum |
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