Literature summary for 5.1.1.11 extracted from

Nguyen Huu, M.C.; von Dungen, A.; Kleinkauf, H.
Irreversible inhibition of the light enzyme of gramicidin S synthetase by halogenomethylketones of phenylalanine (1976), FEBS Lett., 67, 75-79.

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Inhibitors

Inhibitors	Comment	Organism	Structure
L-1-Bromo-3-amino-4-phenyl-butan-2-one	irreversible	Brevibacillus brevis
L-1-Chloro-3-amino-4-phenyl-butan-2-one	irreversible	Brevibacillus brevis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-phenylalanine + H2O	Brevibacillus brevis	phenylalanine racemase, the light component of gramicidin S synthetase, racemizes Phe and activates it to the aminoacyl adenylate and in a second step to the thioester	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Brevibacillus brevis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-Phe + H2O	-	Brevibacillus brevis	AMP + diphosphate + D-Phe	-	?
ATP + L-phenylalanine + H2O	phenylalanine racemase, the light component of gramicidin S synthetase, racemizes Phe and activates it to the aminoacyl adenylate and in a second step to the thioester	Brevibacillus brevis	?	-	?

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Release 2023.1 (January 2023)