Application | Comment | Organism |
---|---|---|
analysis | development of a high resolution correlative combination of cryo soft X-ray tomography to obtain 3D parasite ultrastructure with cryo X-ray fluorescence microscopy to measure heme concentrations | Plasmodium falciparum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
vacuole | - |
Plasmodium falciparum | 5773 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | Q8IL04 | - |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | non-crystalline heme is stored within hemoglobin in the digestive vacuole, and then converted to crystallized heme with the assistance of the heme detoxification protein. A coupling exists between the rate of hemoglobin digestion and the rate of heme dimerization and crystallization. In vivo heme crystallization occurs at a rate of about 1000/s, which is close to the in vitro rate of heme dimerization measured for the heme detoxification protein (HDP). HDP may be primarily responsible for heme crystallization | Plasmodium falciparum |