Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-[2-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-pyridinyl]-3,4-dihydro-2H-1,5-benzodioxepine-7-carboxamide | compound binds the modeled HDP structure in the heme/hemoglobin-binding pockets, and inhibits parasite growth in a dose-dependent manner | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | Q8IL04 | - |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | identification of two heme binding sites and a hemoglobin binding site in Pf HDP. Treatment of Plasmodium falciparum 3D7 parasites with peptide corresponding to the hemoglobin binding domain results in food vacuole abnormalities similar to that seen with cysteine protease inhibitor, E-64 | Plasmodium falciparum |