Crystallization (Comment) | Organism |
---|---|
in complex with dimethyltin, diethyltin, and triethyltin, to 1.53-2.0 A resolution | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dimethyltin | initial binding is to residue D99, and compound subsequently binds to C96, which induces a conformation change in the active site | Escherichia coli | |
trimethyllead | compound is not cleaved and binds only to residue D99 | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P77072 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
diethyllead + H+ | - |
Escherichia coli | 2 ethane + Pb2+ | - |
? | |
diethyltin + 2 H+ | - |
Escherichia coli | 2 ethane + Sn2+ | - |
? | |
additional information | MerB cleavage reaction involves heterolytic carbon-metal bond cleavage, Cys thiol deprotonation, protonation of the formal carbanion, and metal binding to the Cys thiolate. The first two steps are endothermic, and the last two would be exothermic | Escherichia coli | ? | - |
? |