Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
84000 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
protoporphyrin IX + Fe2+ | Homo sapiens | - |
Fe-protoporphyrin IX + 2 H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22830 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
G1E-ER4 cell | - |
Homo sapiens | - |
HEK-293T cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | ATP-binding cassette Abcb7 interacts with the enzyme and Abcb10 in G1E-ER4 cells during differentiation. Formation of a functional ABCB7/enzyme complex is required for enzyme stability and completion of heme synthesis | Homo sapiens | ? | - |
- |
|
protoporphyrin IX + Fe2+ | - |
Homo sapiens | Fe-protoporphyrin IX + 2 H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 40000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
FeCH | - |
Homo sapiens |
ferrochelatase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | a functional complex formed of ATP-binding cassette B7, the enzyme and ATP-binding cassette B10 is required for cellular iron homeostasis, mitochondrial function and heme biosynthesis | Homo sapiens |