Literature summary for 4.98.1.1 extracted from

Maio, N.; Kim, K.S.; Holmes-Hampton, G.; Singh, A.; Rouault, T.A.
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis (2019), Haematologica, 104, 1756-1767 .

Search for more literature for 4.98.1.1

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
84000	-	gel filtration	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
protoporphyrin IX + Fe2+	Homo sapiens	-	Fe-protoporphyrin IX + 2 H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P22830	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
G1E-ER4 cell	-	Homo sapiens	-
HEK-293T cell	-	Homo sapiens	-
HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	ATP-binding cassette Abcb7 interacts with the enzyme and Abcb10 in G1E-ER4 cells during differentiation. Formation of a functional ABCB7/enzyme complex is required for enzyme stability and completion of heme synthesis	Homo sapiens	?	-	-
protoporphyrin IX + Fe2+	-	Homo sapiens	Fe-protoporphyrin IX + 2 H+	-	?

Subunits

Subunits	Comment	Organism
homodimer	2 * 40000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
FeCH	-	Homo sapiens
ferrochelatase	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	a functional complex formed of ATP-binding cassette B7, the enzyme and ATP-binding cassette B10 is required for cellular iron homeostasis, mitochondrial function and heme biosynthesis	Homo sapiens

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Release 2023.1 (January 2023)