Literature summary for 4.98.1.1 extracted from

Qiu, D.; Xie, M.; Dai, J.; An, W.; Wei, H.; Tian, C.; Kempher, M.L.; Zhou, A.; He, Z.; Gu, B.; Zhou, J.
Differential regulation of the two ferrochelatase paralogues in Shewanella loihica PV-4 in response to environmental stresses (2016), Appl. Environ. Microbiol., 82, 5077-5088 .

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Organism

Organism	UniProt	Comment	Textmining
Shewanella loihica	A3QC13	isoform HemH2	-
Shewanella loihica	A3QF47	isoform HemH1	-
Shewanella loihica PV-4	A3QC13	isoform HemH2	-
Shewanella loihica PV-4	A3QF47	isoform HemH1	-

Synonyms

Synonyms	Comment	Organism
HemH1	-	Shewanella loihica
HemH2	-	Shewanella loihica
Shew_1140	-	Shewanella loihica
Shew_2229	-	Shewanella loihica

Expression

Organism	Comment	Expression
Shewanella loihica	isoform HemH1 is constitutively expressed. The transcription of HemH1 is regulated by the housekeeping sigma factor RpoD and potentially regulated by OxyR	additional information
Shewanella loihica	the transcription of HemH2 is regulated by the oxidative stress-associated sigma factor RpoE2	additional information

General Information

General Information	Comment	Organism
physiological function	the disruption of the gene encoding isoform HemH1 results in a significant accumulation of extracellular protoporphyrin IX and decreases intracellular heme levels. Under oxidative stress or exposure of the culture to light, protoporphyrin IX accumulation is suppressed in the HemH1 mutant	Shewanella loihica
physiological function	the expression of isoform HemH2 increases when isoform HemH1 is disrupted. The transcription of HemH2 is regulated by the oxidative stress-associated sigma factor RpoE2	Shewanella loihica

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Release 2023.1 (January 2023)