General Stability | Organism |
---|---|
ferrochelatase shows a calculated half-life of approximately 35 h in vivo | Mus musculus |
ferrochelatase shows a calculated half-life of approximately 35 h in vivo | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | the posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability. Decreased Fe-S cluster availability because of cellular iron depletion or impaired Fe-S cluster assembly causes reduced maturation and stabilization of apoferrochelatase | Mus musculus | |
Fe2+ | the posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability. Decreased Fe-S cluster availability because of cellular iron depletion or impaired Fe-S cluster assembly causes reduced maturation and stabilization of apoferrochelatase | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
40000 | - |
x * 40000, SDS-PAGE | Mus musculus |
40000 | - |
x * 40000, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Oxidation Stability | Organism |
---|---|
FECH is destabilized by oxygen and mitochondrial oxidative stress | Mus musculus |
FECH is destabilized by oxygen and mitochondrial oxidative stress | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythroblast | splenic erythroblast | Mus musculus | - |
erythroleukemia cell | - |
Mus musculus | - |
muscle | - |
Homo sapiens | - |
myoblast | - |
Homo sapiens | - |
spleen | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deuteroporphyrin IX + Zn2+ | - |
Mus musculus | Zn-deuteroporphyrin IX + H+ | - |
? | |
deuteroporphyrin IX + Zn2+ | - |
Homo sapiens | Zn-deuteroporphyrin IX + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 40000, SDS-PAGE | Mus musculus |
? | x * 40000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
FeCH | - |
Mus musculus |
FeCH | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
[2Fe-2S]-center | ferrochelatase possesses an iron-sulfur [2Fe-2S] cluster that does not participate in catalysis | Mus musculus | |
[2Fe-2S]-center | ferrochelatase possesses an iron-sulfur [2Fe-2S] cluster that does not participate in catalysis | Homo sapiens |