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Literature summary for 4.98.1.1 extracted from
- The heme synthesis defect of mutants impaired in mitochondrial iron-sulfur protein biogenesis is caused by reversible inhibition of ferrochelatase (2004), J. Biol. Chem., 279, 29101-29108.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | unknown mitochondrial compound with a molecular mass greater than 10 kD, reversible inhibition | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protoporphyrin + Fe2+ | Saccharomyces cerevisiae | - |
protoheme + 2 H+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | P16622 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| immunopurification from mitochondrial extracts | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deuteroporphyrin + Fe2+ | - |
Saccharomyces cerevisiae | deuteroheme + 2 H+ | - |
? | |
| protoporphyrin + Fe2+ | - |
Saccharomyces cerevisiae | protoheme + 2 H+ | - |
? | |
| protoporphyrin IX + Zn2+ | - |
Saccharomyces cerevisiae | Zn-protoporphyrin + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ferrochelatase | - |
Saccharomyces cerevisiae |
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