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Literature summary for 4.98.1.1 extracted from

  • Franco, R.; Bai, G.; Prosinecki, V.; Abrunhosa, F.; Ferreira, G.C.; Bastos, M.
    Porphyrin-substrate binding to murine ferrochelatase: effect on the thermal stability of the enzyme (2005), Biochem. J., 386, 599-605.
    View publication on PubMed
Search for more literature for 4.98.1.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli, wild-type and mutants E289Q and E289A Mus musculus

Protein Variants

Protein Variants Comment Organism
E289A enhanced protein stability Mus musculus
E289Q enhanced protein stability Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protoporphyrin + Fe2+ Mus musculus
-
 protoheme + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P22315
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mesoporphyrin + Fe2+ pH 8.0 Mus musculus mesoheme
-
 ?
protoporphyrin + Fe2+
-
 Mus musculus protoheme + H+
-
 ?
protoporphyrin IX + Zn2+
-
 Mus musculus Zn-protoporphyrin IX
-
 ?

Synonyms

Synonyms Comment Organism
ferrochelatase
-
 Mus musculus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
55.8
-
 Tm, wild-type in phosphate buffer Mus musculus
56
-
 Tm, wild-type in bicine buffer Mus musculus
57.5
-
 Tm, mutant E289A Mus musculus
61
-
 Tm, mutant E289Q Mus musculus