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Literature summary for 4.98.1.1 extracted from

  • Dailey, H.A.; Dailey, T.A.; Wu, C.K.; Medlock, A.E.; Wang, K.F.; Rose, J.P.; Wang, B.C.
    Ferrochelatase at the millennium: structures, mechanisms and [2Fe-2S] clusters (2000), Cell. Mol. Life Sci., 57, 1909-1926.
    View publication on PubMed

Application

Application Comment Organism
medicine involvement in erythropoietic protoporphyria, overview Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Homo sapiens
overview Bacillus subtilis

Inhibitors

Inhibitors Comment Organism Structure
Cd2+
-
Mus musculus
Hg2+
-
Mus musculus
metalloporphyrin containing Fe2+, Co2+, Zn2+, Sn2+ Mus musculus
Mn2+
-
Mus musculus
Pb2+
-
Mus musculus
porphyrin isomer competitive Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane attached to Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
2 * 42000, SDS-PAGE, crystallographic data Homo sapiens

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Cereibacter sphaeroides
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
protoheme + 2 H+ = protoporphyrin + Fe2+ mechanism: overview Bacillus subtilis
protoheme + 2 H+ = protoporphyrin + Fe2+ mechanism: overview Homo sapiens
protoheme + 2 H+ = protoporphyrin + Fe2+ mechanism: overview Cereibacter sphaeroides

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
overview: assay methods Bacillus subtilis
additional information
-
overview: assay methods Cereibacter sphaeroides
additional information
-
overview on assay methods Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,4-disulfonic deuteroporphyrin + Fe2+
-
Cereibacter sphaeroides ?
-
?
additional information metal substrates are Fe2+, Zn2+, Co2+ Homo sapiens ?
-
?
additional information metal substrates are Fe2+, Zn2+, Cu2+, no substrate: Co2+, Fe3+ Bacillus subtilis ?
-
?

Subunits

Subunits Comment Organism
dimer 2 * 42000, SDS-PAGE, crystallographic data Homo sapiens
monomer crystallographic data Bacillus subtilis

Cofactor

Cofactor Comment Organism Structure
additional information [2FE-2S]-cluster, one cluster per monomer, overview Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information Ki-values of porphyrin isomers that are not substrates are in the range of 0.013-0.07 mM, Ki-values of metalloporphyrin isomers that are not substrates are in the range of 0.002-0.013 mM, Ki-values for metal inhibitors are in the range of 0.01-0.05 mM Mus musculus