Application | Comment | Organism |
---|---|---|
medicine | involvement in erythropoietic protoporphyria, overview | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
- |
Homo sapiens |
overview | Bacillus subtilis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cd2+ | - |
Mus musculus | |
Hg2+ | - |
Mus musculus | |
metalloporphyrin | containing Fe2+, Co2+, Zn2+, Sn2+ | Mus musculus | |
Mn2+ | - |
Mus musculus | |
Pb2+ | - |
Mus musculus | |
porphyrin isomer | competitive | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | attached to | Homo sapiens | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42000 | - |
2 * 42000, SDS-PAGE, crystallographic data | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus subtilis | - |
- |
- |
Cereibacter sphaeroides | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
protoheme + 2 H+ = protoporphyrin + Fe2+ | mechanism: overview | Bacillus subtilis | |
protoheme + 2 H+ = protoporphyrin + Fe2+ | mechanism: overview | Homo sapiens | |
protoheme + 2 H+ = protoporphyrin + Fe2+ | mechanism: overview | Cereibacter sphaeroides |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
overview: assay methods | Bacillus subtilis |
additional information | - |
overview: assay methods | Cereibacter sphaeroides |
additional information | - |
overview on assay methods | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,4-disulfonic deuteroporphyrin + Fe2+ | - |
Cereibacter sphaeroides | ? | - |
? | |
additional information | metal substrates are Fe2+, Zn2+, Co2+ | Homo sapiens | ? | - |
? | |
additional information | metal substrates are Fe2+, Zn2+, Cu2+, no substrate: Co2+, Fe3+ | Bacillus subtilis | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 42000, SDS-PAGE, crystallographic data | Homo sapiens |
monomer | crystallographic data | Bacillus subtilis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | [2FE-2S]-cluster, one cluster per monomer, overview | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Ki-values of porphyrin isomers that are not substrates are in the range of 0.013-0.07 mM, Ki-values of metalloporphyrin isomers that are not substrates are in the range of 0.002-0.013 mM, Ki-values for metal inhibitors are in the range of 0.01-0.05 mM | Mus musculus |