Literature summary for 4.98.1.1 extracted from

Jacobs, J.M.; Sinclair, P.R.; Sinclair, J.F.; Gorman, N.; Walton, H.S.; Wood, S.G.; Nichols, C.
Formation of zinc protoporphyrin in cultured hepatocytes: effects of ferrochelatase inhibition, iron chelation or lead (1998), Toxicology, 125, 95-105.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2,2'-dipyridyl	-	Rattus norvegicus
N-methylmesoporphyrin	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
protoporphyrin IX + Fe2+	Gallus gallus	final step of heme biosynthesis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Gallus gallus	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	embryonal, cultured	Gallus gallus	-
hepatocyte	embryonal, cultured	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
protoporphyrin + Fe2+	-	Gallus gallus	protoheme + 2 H+	-	?
protoporphyrin + Fe2+	-	Rattus norvegicus	protoheme + 2 H+	-	?
protoporphyrin + Zn2+	-	Rattus norvegicus	Zn2+-protoporphyrin + H+	-	?
protoporphyrin IX + Fe2+	final step of heme biosynthesis	Gallus gallus	?	-	?

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Release 2023.1 (January 2023)