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Literature summary for 4.6.1.24 extracted from

  • Mitkevich, V.A.; Tchurikov, N.A.; Zelenikhin, P.V.; Petrushanko, I.Y.; Makarov, A.A.; Ilinskaya, O.N.
    Binase cleaves cellular noncoding RNAs and affects coding mRNAs (2010), FEBS J., 277, 186-196.
    View publication on PubMed
Search for more literature for 4.6.1.24

Application

Application Comment Organism
drug development bacterial RNases are promising tools for the development of anticancer drugs. Binase affects the total amount of intracellular RNA and the expression of proapoptotic and antiapoptotic mRNAs Bacillus intermedius

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21 carrying plasmid pGEMGX1/ent/Bi as a homogeneous protein Bacillus intermedius

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
12300
-
-
 Bacillus intermedius

Organism

Organism UniProt Comment Textmining
Bacillus intermedius P00649
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bacillus intermedius

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information in vivo binase affects the quantity of proapoptotic and antiapoptotic mRNAs, as expression of the p53 and hSK4 genes is increased and expression of the bcl-2 gene is reduced Bacillus intermedius ?
-
 ?

Synonyms

Synonyms Comment Organism
Binase
-
 Bacillus intermedius

Expression

Organism Comment Expression
Bacillus intermedius upregulation of the KCa channels and the apoptotic p53 genes, downregulation of the antiapoptotic bcl-2 gene under binase action up

General Information

General Information Comment Organism
physiological function binase is a regulator of RNA-dependent processes of cell proliferation and apoptosis. Binase affects the total amount of intracellular RNA and the expression of proapoptotic and antiapoptotic mRNAs Bacillus intermedius