Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.23 extracted from

  • Perez-Canadillas, J.M.; Santoro, J.; Campos-Olivas, R.; Lacadena, J.; Martinez del Pozo, A.; Gavilanes, J.G.; Rico, M.; Bruix, M.
    The highly refined solution structure of the cytotoxic ribonuclease alpha-sarcin reveals the structural requirements for substrate recognition and ribonucleolytic activity (2000), J. Mol. Biol., 299, 1061-1073.
    View publication on PubMed
Search for more literature for 4.6.1.23

Application

Application Comment Organism
medicine alpha-sarcin inhibits growth of tumors by inhibition of protein synthesis, protein induces apoptosis in tumor cells after internalization via endocytosis, alpha-sarcin is cytotoxic for normal human cells and for many tumor cell lines, particulary sarcoma and carcinoma, it shows a selective, high level of toxicity against cells with altered or damaged cell membranes, it is a promising candidate for the treatment of cancer and viral infections such as AIDS Aspergillus giganteus

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Aspergillus giganteus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Aspergillus giganteus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
rRNA + H2O Aspergillus giganteus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus giganteus P00655 filamentous fungus, mold
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information alpha-sarcin site nucleotide sequence is identical in the large rRNAs of cytoplasmic ribosomes from a range of evolutionary diverse organisms, evolutionarily conserved in all eukaryotes and prokaryotes so far tested Aspergillus giganteus ?
-
 ?
rRNA + H2O
-
 Aspergillus giganteus ?
-
 ?