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Literature summary for 4.6.1.23 extracted from
- Thermal unfolding of the cytotoxin alpha-sarcin: phospholipid binding induces destabilization of the protein structure (1995), Biochim. Biophys. Acta, 1252, 126-134.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | alpha-sarcin inhibits growth of tumors by inhibition of protein synthesis, protein induces apoptosis in tumor cells after internalization via endocytosis, alpha-sarcin is cytotoxic for normal human cells and for many tumor cell lines, particulary sarcoma and carcinoma, it shows a selective, high level of toxicity against cells with altered or damaged cell membranes, it is a promising candidate for the treatment of cancer and viral infections such as AIDS | Aspergillus giganteus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 16500 | - |
- |
Aspergillus giganteus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| rRNA + H2O | Aspergillus giganteus | - |
? | - |
? |  |
| rRNA + H2O | Aspergillus giganteus MDH 18894 | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus giganteus | - |
MDH 18894 | - |
| Aspergillus giganteus | - |
filamentous fungus, mold | - |
| Aspergillus giganteus MDH 18894 | - |
MDH 18894 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Aspergillus giganteus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | specific ribonuclease activity against ribosomal RNA causes ribosome disruption and subsequent protein biosynthesis inhibition | Aspergillus giganteus | ? | - |
? | |
| additional information | specific ribonuclease activity against ribosomal RNA causes ribosome disruption and subsequent protein biosynthesis inhibition | Aspergillus giganteus MDH 18894 | ? | - |
? | |
| rRNA + H2O | - |
Aspergillus giganteus | ? | - |
? | |
| rRNA + H2O | - |
Aspergillus giganteus MDH 18894 | ? | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 52.6 | - |
transition temperature Tm | Aspergillus giganteus |
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Release 2023.1 (January 2023)
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