Any feedback?
Literature summary for 4.6.1.22 extracted from
- Initiation of decay of Bacillus subtilis rpsO mRNA by endoribonuclease RNase Y (2010), J. Bacteriol., 192, 3279-3286.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| rpsO mRNA + H2O | Bacillus subtilis | aspects of mRNA decay initiation in Bacillus subtilis. Endonuclease cleavage in the body of the message, rather than degradation from the native 3' end, is the rate-determining step for mRNA decay | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
gene ymdA encoding RNase Y | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| rpsO mRNA + H2O | aspects of mRNA decay initiation in Bacillus subtilis. Endonuclease cleavage in the body of the message, rather than degradation from the native 3' end, is the rate-determining step for mRNA decay | Bacillus subtilis | ? | - |
? | |
| rpsO mRNA + H2O | a small monocistronic mRNA, decay of rpsO mRNA in a panel of 3'-to-5' exoribonuclease mutants, overview. Endonuclease cleavage in the body of the message, rather than degradation from the native 3' end, is the rate-determining step for mRNA decay | Bacillus subtilis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| endoribonuclease RNase Y | - |
Bacillus subtilis |
| RNase Y | - |
Bacillus subtilis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | rpsO mRNA half-life is unchanged in a strain that has decreased RNase J1 activity and no RNase J2 activity, but it is 2.3fold higher in a strain with decreased activity of RNase Y | Bacillus subtilis |
| metabolism | Bacillus subtilis endonucleases Bs-RNase III, RNase M5, RNase P, RNase Z, EndoA, and Mini-III are not involved in rpsO mRNA decay, the upstream products are degraded by polynucleotide phosphorylase (PNPase), and the downstream products were degraded by the 5' exonuclease activity of RNase J1 | Bacillus subtilis |
| physiological function | RNase Y mediates the initiation of rpsO mRNA decay, the stability of the specific mRNA is determined by RNase Y | Bacillus subtilis |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
