Cloned (Comment) | Organism |
---|---|
cloning of cdiA-CTECL under the control of an arabinose-inducible promoter and expression in Escherichia coli, which leads to growth inhibition of the bacterial cells | Enterobacter cloacae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | CdiA-CT toxins are specifically neutralized by cognate CdiI immunity proteins to protect toxin-producing cells from autoinhibition | Enterobacter cloacae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Enterobacter cloacae | the CdiA-CTECL toxin has 16S rRNase activity | ? | - |
? | |
additional information | Enterobacter cloacae ATCC 13047 | the CdiA-CTECL toxin has 16S rRNase activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Enterobacter cloacae | - |
- |
- |
Enterobacter cloacae ATCC 13047 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the CdiA-CTECL toxin has 16S rRNase activity | Enterobacter cloacae | ? | - |
? | |
additional information | the CdiA-CTECL toxin has 16S rRNase activity | Enterobacter cloacae ATCC 13047 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CdiA-CT toxin | - |
Enterobacter cloacae |
General Information | Comment | Organism |
---|---|---|
additional information | the three-dimensional structure of enzyme CdiA-CTECL reveals similarity to the C-terminal nuclease domain of colicin E3. The resolved C-terminal domain of enzyme CdiA-CTECL consists of an N-terminal alpha helix, followed by a twisted five-stranded antiparallel beta sheet. The domain contains two long loops, L2 and L4, which connect beta1 to beta2 and beta3 to beta4, respectively | Enterobacter cloacae |
physiological function | the 16S rRNase enzyme is a contact-dependent growth inhibition toxin unvolved in inter-bacterial competition. CdiA-CTECL cleaves 16S rRNA in vivo to inhibit cell growth, overview | Enterobacter cloacae |