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Literature summary for 4.6.1.21 extracted from

  • Beck, C.; Morse, R.; Cunningham, D.; Iniguez, A.; Low, D.; Goulding, C.; Hayes, C.
    CdiA from enterobacter cloacae delivers a toxic ribosomal RNase into target bacteria (2014), Structure, 22, 707-718.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
cloning of cdiA-CTECL under the control of an arabinose-inducible promoter and expression in Escherichia coli, which leads to growth inhibition of the bacterial cells Enterobacter cloacae

Inhibitors

Inhibitors Comment Organism Structure
additional information CdiA-CT toxins are specifically neutralized by cognate CdiI immunity proteins to protect toxin-producing cells from autoinhibition Enterobacter cloacae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Enterobacter cloacae the CdiA-CTECL toxin has 16S rRNase activity ?
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?
additional information Enterobacter cloacae ATCC 13047 the CdiA-CTECL toxin has 16S rRNase activity ?
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?

Organism

Organism UniProt Comment Textmining
Enterobacter cloacae
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Enterobacter cloacae ATCC 13047
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the CdiA-CTECL toxin has 16S rRNase activity Enterobacter cloacae ?
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?
additional information the CdiA-CTECL toxin has 16S rRNase activity Enterobacter cloacae ATCC 13047 ?
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?

Synonyms

Synonyms Comment Organism
CdiA-CT toxin
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Enterobacter cloacae

General Information

General Information Comment Organism
additional information the three-dimensional structure of enzyme CdiA-CTECL reveals similarity to the C-terminal nuclease domain of colicin E3. The resolved C-terminal domain of enzyme CdiA-CTECL consists of an N-terminal alpha helix, followed by a twisted five-stranded antiparallel beta sheet. The domain contains two long loops, L2 and L4, which connect beta1 to beta2 and beta3 to beta4, respectively Enterobacter cloacae
physiological function the 16S rRNase enzyme is a contact-dependent growth inhibition toxin unvolved in inter-bacterial competition. CdiA-CTECL cleaves 16S rRNA in vivo to inhibit cell growth, overview Enterobacter cloacae