Literature summary for 4.6.1.20 extracted from

Nabavi, S.; Nazar, R.N.
Pac1 endonuclease and Dhp1p 5'-3' exonuclease are required for U3 snoRNA termination in Schizosaccharomyces pombe (2010), FEBS Lett., 584, 3436-3441.

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Cloned(Commentary)

Cloned (Comment)	Organism
Pac1 endonuclease cleavage is required for U3 snoRNA gene transcription termination and RNA maturation, the degree of cleavage correlates closely with both RNA maturation and transcript termination. U3B snoRNA gene expression system containing a tagged Schizosaccharomyces pombe snU32 locus expressed under its own promoter and the dominant plasmid-derived U3B snoRNA	Schizosaccharomyces pombe

Organism

Organism	UniProt	Comment	Textmining
Schizosaccharomyces pombe	-	-	-
Schizosaccharomyces pombe GP969	-	-	-

General Information

General Information	Comment	Organism
additional information	cleavage in the U3 snoRNA transcripts of Schizosaccharomyces pombe can induce transcript termination, the degree of cleavage correlates closely with both RNA maturation and transcript termination. the RNase III-like endonuclease, Pac1, and the nuclear 50-exonuclease, Dhp1p, are essential for RNA production and transcript termination, supporting a reversed torpedoes model in which the endonuclease cut allows 5'- and 3'-exonuclease activities access to the transcript, leading simultaneously to transcript termination in one direction and RNA maturation in the other	Schizosaccharomyces pombe

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Release 2023.1 (January 2023)