Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.2 extracted from

  • Iino, S.; Horiguchi, K.; Nojyo, Y.
    Interstitial cells of Cajal are innervated by nitrergic nerves and express nitric oxide-sensitive guanylate cyclase in the guinea-pig gastrointestinal tract (2008), Neuroscience, 152, 437-448.
    View publication on PubMed
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
NO nitric oxide-sensitive guanylate cyclase Cavia porcellus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Cavia porcellus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Cavia porcellus NO is a major signaling molecule in the gastrointestinal tract, and released NO inhibits muscular contraction. The actions of NO are mediated by stimulation of NO-sensitive sGC and a subsequent increase in cGMP concentration 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
 adult female Hartley guinea pigs
-

Source Tissue

Source Tissue Comment Organism Textmining
blood vessel smooth muscle Cavia porcellus
-
colon smooth muscle, low enzyme expression Cavia porcellus
-
gastrointestinal tract smooth muscle and myenteric layer Cavia porcellus
-
large intestine
-
 Cavia porcellus
-
additional information analysis of sGC in gastrointestinal tissue, immunohistochemic analysis Cavia porcellus
-
neuron
-
 Cavia porcellus
-
smooth muscle gastrointestinal tract, muscularis mucosae and vasculature Cavia porcellus
-
stomach smooth muscle, low enzyme expression Cavia porcellus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Cavia porcellus 3',5'-cyclic GMP + diphosphate
-
 ?
GTP NO is a major signaling molecule in the gastrointestinal tract, and released NO inhibits muscular contraction. The actions of NO are mediated by stimulation of NO-sensitive sGC and a subsequent increase in cGMP concentration Cavia porcellus 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
nitric oxide-sensitive guanylate cyclase
-
 Cavia porcellus
NO-sensitive GC
-
 Cavia porcellus
sGC
-
 Cavia porcellus
soluble guanylate cyclase
-
 Cavia porcellus