Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.2 extracted from

  • Schmidtko, A.; Gao, W.; Koenig, P.; Heine, S.; Motterlini, R.; Ruth, P.; Schlossmann, J.; Koesling, D.; Niederberger, E.; Tegeder, I.; Friebe, A.; Geisslinger, G.
    cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I (2008), J. Neurosci., 28, 8568-8576.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Protein Variants

Protein Variants Comment Organism
additional information nociceptive behavior of mice deficient in NO-sensitive guanylyl cyclase, GC-KO mice fail to develop pain sensitization induced by intrathecal administration of drugs releasing NO or carbon monoxide, NO-, CO-, and cGMP-induced pain behavior in GC-KO mice, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Mus musculus NO-GC plays a role in neuropathic pain. cGMP produced by NO-GC may activate signaling pathways different from cGMP-dependent protein kinase I, cGKI, during spinal nociceptive processing, whereas cGKI can be activated by natriuretic peptide receptor-B dependent cGMP production, overview 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ganglion dorsal root ganglion, NO-GC is restricted to non-neuronal cells in dorsal root ganglia Mus musculus
-
spinal cord NO-GC is distinctly expressed in neurons of the mouse dorsal horn Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?
GTP NO-GC plays a role in neuropathic pain. cGMP produced by NO-GC may activate signaling pathways different from cGMP-dependent protein kinase I, cGKI, during spinal nociceptive processing, whereas cGKI can be activated by natriuretic peptide receptor-B dependent cGMP production, overview Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
NO-GC
-
 Mus musculus
NO-sensitive guanylyl cyclase
-
 Mus musculus