Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.2 extracted from

  • Makino, C.L.; Peshenko, I.V.; Wen, X.H.; Olshevskaya, E.V.; Barrett, R.; Dizhoor, A.M.
    A role for GCAP2 in regulating the photoresponse. Guanylyl cyclase activation and rod electrophysiology in GUCA1B knock-out mice (2008), J. Biol. Chem., 283, 29135-29143.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
neuronal calcium sensor GCAP1 confers Ca2+ sensitivity to guanylyl cyclase activity Mus musculus
neuronal calcium sensor GCAP2 confers Ca2+ sensitivity to guanylyl cyclase activity, absence of GCAP2 affected guanylyl cyclase activity in two ways: 1. the maximal rate of cGMP synthesis at low [Ca2] dropps 2fold and 2. the half-maximal rate of cGMP synthesis is attained at a higher than normal [Ca2+], phenotype of GCAP2 knockout mice, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ the two neuronal calcium sensors, GCAP1 and GCAP2, confer Ca2+ sensitivity to guanylyl cyclase activity Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Mus musculus the retina-specific guanylyl cyclases, retGC1 and retGC2 support synthesis of cGMP in photoreceptors 3',5'-cyclic GMP + diphosphate cyclic GMP serves as the second messenger in visual transduction, linking photon absorption by rhodopsin to the activity of ion channels ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 isozyme retGC
-

Source Tissue

Source Tissue Comment Organism Textmining
retina
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?
GTP the retina-specific guanylyl cyclases, retGC1 and retGC2 support synthesis of cGMP in photoreceptors Mus musculus 3',5'-cyclic GMP + diphosphate cyclic GMP serves as the second messenger in visual transduction, linking photon absorption by rhodopsin to the activity of ion channels ?

Synonyms

Synonyms Comment Organism
retGC
-
 Mus musculus
retinal membrane guanylyl cyclase
-
 Mus musculus