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Literature summary for 4.6.1.2 extracted from

  • Zhang, Q.; Saito, Y.; Naya, N.; Imagawa, K.; Somekawa, S.; Kawata, H.; Takeda, Y.; Uemura, S.; Kishimoto, I.; Nakao, K.
    The specific mineralocorticoid receptor blocker eplerenone attenuates left ventricular remodeling in mice lacking the gene encoding guanylyl cyclase-A (2008), Hypertens. Res., 31, 1251-1256.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information mice deficient in isozyme GC-A show marked cardiac hypertrophy and fibrosis, which can be inhibited by both genetic and pharmacological blockade of type 1 angiotensin II receptors. The mutant mice show increased expression of atrial and brain natriuretic peptides, and increased systemic blood pressure and heart weight to body weight ratios compared to the wild-type mice, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Mus musculus isozyme GC-A is a common receptor for atrial and brain natriuretic peptide 3',5'-cyclic GMP + diphosphate
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
atrium
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 Mus musculus
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brain
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
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 Mus musculus 3',5'-cyclic GMP + diphosphate
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 ?
GTP isozyme GC-A is a common receptor for atrial and brain natriuretic peptide Mus musculus 3',5'-cyclic GMP + diphosphate
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 ?

Synonyms

Synonyms Comment Organism
guanylyl cyclase-A
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 Mus musculus