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Literature summary for 4.6.1.2 extracted from

  • Dhaese, I.; Vanneste, G.; Sips, P.; Buys, E.; Brouckaert, P.; Lefebvre, R.A.
    Involvement of soluble guanylate cyclase alpha1 and alpha2, and SKCa channels in NANC relaxation of mouse distal colon (2008), Eur. J. Pharmacol., 589, 251-259.
    View publication on PubMed
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
NO NO, acting via isozyme sGCalpha1beta1, is the principal neurotransmitter in electrical field stimulation-evoked responses Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information basal cGMP levels are lower in sGCalpha1 knockout strips but NO still significantly increases cGMP levels versus basal. In conclusion, in the absence of sGCalpha1beta1, exogenous NO is able to partially act through sGCalpha2beta1, comparison of the soluble guanylate cyclase (sGC) isoforms ?1?1 and ?2?1, and of wild-type with sGCalpha1 knockout mice in the relaxation of distal colon by exogenous NO and by NANC nerve stimulation, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
8-bromo-cGMP
-
 Mus musculus
[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Mus musculus the soluble guanylate cyclase isoforms alpha1beta1 and alpha2beta1 are involved in the relaxation of distal colon by exogenous NO and by NANC nerve stimulation, mechanism, overview 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 Swiss/129 mice, isozymes soluble guanylate cyclase alpha1beta and alpha2beta1
-

Source Tissue

Source Tissue Comment Organism Textmining
colon distal Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?
GTP the soluble guanylate cyclase isoforms alpha1beta1 and alpha2beta1 are involved in the relaxation of distal colon by exogenous NO and by NANC nerve stimulation, mechanism, overview Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Mus musculus
soluble guanylate cyclase
-
 Mus musculus
soluble guanylate cyclase alpha1
-
 Mus musculus
soluble guanylate cyclase alpha2
-
 Mus musculus