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Literature summary for 4.6.1.2 extracted from

  • Schreier, B.; Boerner, S.; Voelker, K.; Gambaryan, S.; Schaefer, S.C.; Kuhlencordt, P.; Gassner, B.; Kuhn, M.
    The heart communicates with the endothelium through the guanylyl cyclase-A receptor: acute handling of intravascular volume in response to volume expansion (2008), Endocrinology, 149, 4193-4199.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Protein Variants

Protein Variants Comment Organism
additional information construction of GC-A knockout mice that show significant chronic hypervolemic hypertension, phenotype, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Mus musculus GC-A acts as receptor for atrial natriuretic peptide that regulates arterial blood pressure and volume, overview 3',5'-cyclic GMP + diphosphate
-
 ?
additional information Mus musculus the atrial natriuretic peptide/GC-A/cGMP-dependent protein kinase I system stimulates the phosphorylation of VASP in cultured microvascular endothelial cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelium vascular Mus musculus
-
heart
-
 Mus musculus
-
vascular system
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?
GTP GC-A acts as receptor for atrial natriuretic peptide that regulates arterial blood pressure and volume, overview Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?
additional information the atrial natriuretic peptide/GC-A/cGMP-dependent protein kinase I system stimulates the phosphorylation of VASP in cultured microvascular endothelial cells Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
GC-A receptor
-
 Mus musculus
guanylyl cyclase-A receptor
-
 Mus musculus