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Literature summary for 4.6.1.2 extracted from

  • Perkins, W.J.; Kost, S.L.; Danielson, M.A.
    Prolonged NO treatment decreases alpha adrenoreceptor agonist responsiveness in porcine pulmonary artery due to persistent soluble guanylyl cyclase activation (2009), Am. J. Physiol. Lung Cell Mol. Physiol., 296, 666-673.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
additional information NO treatment elevates the enzyme activity shortly after application, but does not significantly affect the steady-state levels of cGMP Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
1H-[1,2,4]oxadiazolo[4,3a]quinoxalin-1-one acute addition to pulmonary artery does not affect phenylephrine responsiveness, but restores the responsiveness in pulmonary artery treated with an NO-donor, overview Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Sus scrofa
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Sus scrofa
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
artery pulmonary, cultured model Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.29
-
 pulmonary artery homogenate in absence of NO Sus scrofa
0.53
-
 pulmonary artery homogenate after 24 h of treatment with NO Sus scrofa
1.38
-
 pulmonary artery homogenate after 2 h of treatment with NO Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Sus scrofa 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Sus scrofa
soluble guanylyl cyclase
-
 Sus scrofa