Literature summary for 4.6.1.2 extracted from

Zhou, Z.; Pyriochou, A.; Kotanidou, A.; Dalkas, G.; van Eickels, M.; Spyroulias, G.; Roussos, C.; Papapetropoulos, A.
Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress (2008), Am. J. Physiol. Heart Circ. Physiol., 295, H1763-H1771.

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Activating Compound

Activating Compound	Comment	Organism	Structure
3-morpholinosydnonimine	i.e. SIN-1	Mus musculus
BAY 41-2272	-	Mus musculus
H2O2	activates the enzyme, and reduces the cGMP formation activation by nitroprusside and BAY 41-2272 in smooth muscle cells, but enhances the response to HMR-1766, the activation by reactive oxigen species is heme-dependent	Mus musculus
HMR-1766	stimulates the enzyme, especially heme-free sGC, identification of the interaction region and binding structure of the enzyme by computational modelling	Mus musculus
menadione	-	Mus musculus
nitroprusside	-	Mus musculus
rotenone	-	Mus musculus
[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one	potentiates the activating effect of HMR-1766 on the wild-type enzyme	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
expression of the heme-free alpha1-subunit/H105F beta1-subunit sGC mutant in COS-7 cells	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
H105F	the enzyme of heme-free alpha1-subunit/H105F beta1-subunit sGC mutant is not activated by sodium nitroprusside, but by HMR-1766, 1H-[1,2,4]oxidazolol[4,3a]quinoxalin-1-one does not potentiate the activating effect of HMR-1766 in mutant cells, while it does in wild-type cells, binding structure of H105F mutant with HMR-1766, overview	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one	inhibits the enzyme and the enzyme activating effect of sodium nitroprusside	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP	Mus musculus	-	3',5'-cyclic GMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
smooth muscle cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP	-	Mus musculus	3',5'-cyclic GMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
sGC	-	Mus musculus
soluble guanylyl cyclase	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
heme	-	Mus musculus

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Release 2023.1 (January 2023)