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Literature summary for 4.6.1.19 extracted from

  • Ambrosio, L.; Morriss, S.; Riaz, A.; Bailey, R.; Ding, J.; MacIntosh, G.C.
    Phylogenetic analyses and characterization of RNase X25 from Drosophila melanogaster suggest a conserved housekeeping role and additional functions for RNase T2 enzymes in protostomes (2014), PLoS ONE, 9, e105444.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.19

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, phylogenetic analysis Drosophila melanogaster

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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-
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Drosophila melanogaster w1118/w1118
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-
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Protostomia
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Source Tissue

Source Tissue Comment Organism Textmining
additional information developmental profile of Drosophila melanogaster enzyme activities, overview Drosophila melanogaster
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information assay substrate is Torula yeast RNA Drosophila melanogaster ?
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 ?
additional information assay substrate is Torula yeast RNA Drosophila melanogaster w1118/w1118 ?
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 ?

Synonyms

Synonyms Comment Organism
RNase T2
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 Drosophila melanogaster
RNase T2
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 Protostomia
RNase X25
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 Drosophila melanogaster

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 assay at, the enzyme has an acidic pH preference Drosophila melanogaster

Expression

Organism Comment Expression
Drosophila melanogaster RNase X25 enzyme expression is elevated in response to nutritional and oxidative stresses up

General Information

General Information Comment Organism
evolution RNase T2 family, phylogenetic analysis, gene duplication events seem to have happened independently in each phylum. RNase T2 genes have undergone duplication events followed by divergence in several phyla, including the loss of catalytic residues, and suggest that RNase T2 proteins have acquired additional functions. Among those, it is likely that a role in host immunosuppression evolved independently in several groups, including parasitic Platyhelminthes and parasitoid wasps Protostomia
evolution RNase X25 belongs to the RNase T2 family which harbors enzymes associated with the secretory pathway that are almost absolutely conserved in all eukaryote Drosophila melanogaster
metabolism cellular functions of RNase T2 proteins are associated with RNA recycling and maintenance of cellular homeostasis Drosophila melanogaster
physiological function RNase X25 enzyme has a housekeeping role in recycling RNA and in stress responses, it is the major contributor of ribonuclease activity in flies, correlation between induction of RNase X25 expression and autophagy Drosophila melanogaster