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Literature summary for 4.6.1.19 extracted from

  • Banerjee, S.; Chakrabarti, A.; Jha, B.K.; Weiss, S.R.; Silverman, R.H.
    Cell-type-specific effects of RNase L on viral induction of beta interferon (2014), mBio, 5, e00856.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.19

Activating Compound

Activating Compound Comment Organism Structure
2',5'-Oligoadenylate binds to and activates the enzyme. It is produced in response to viral double-stranded RNA by the 2',5'-oligoadenylate synthetase Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic fibroblast
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
RNase L
-
 Mus musculus

General Information

General Information Comment Organism
metabolism the interferon-inducible antiviral state is mediated in part by the 2',5'-oligoadenylate synthetase/RNase L system Mus musculus
physiological function direct activation of the enzyme by transfection with 2',5'-oligoadenylate induces IFN-beta in embryonic fibroblasts but not in macrophages, RNA damage from the enzyme in virus-infected macrophages is likely responsible for reducing IFN-beta production. Apoptosis is known to occur in cells that sustain high levels of RNA damage due to RNase L enzyme activity Mus musculus