Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.19 extracted from

  • Hillwig, M.; Rizhsky, L.; Wang, Y.; Umanskaya, A.; Essner, J.; MacIntosh, G.
    Zebrafish RNase T2 genes and the evolution of secretory ribonucleases in animals (2009), BMC Evol. Biol., 9, 170.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.19

Cloned(Commentary)

Cloned (Comment) Organism
using pGEM-T Easy vector Danio rerio

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
23700
-
 sequence analysis Danio rerio
23700
-
 x * 23700, calculated from sequence Danio rerio
25400
-
 sequence analysis Danio rerio
27300
-
 sequence analysis Danio rerio

Organism

Organism UniProt Comment Textmining
Danio rerio B8XY54
-
-
Danio rerio B8XY55
-
-
Danio rerio B8XY56
-
-

Purification (Commentary)

Purification (Comment) Organism
by gel filtration Danio rerio

Source Tissue

Source Tissue Comment Organism Textmining
adult in all tissues Danio rerio
-
brain
-
 Danio rerio
-
embryo in all tissues Danio rerio
-
eye
-
 Danio rerio
-
eye low level of RNase Dre1 Danio rerio
-
gut
-
 Danio rerio
-
heart
-
 Danio rerio
-
liver
-
 Danio rerio
-
additional information RNase Dre1 is absent from liver Danio rerio
-
muscle
-
 Danio rerio
-
ovary
-
 Danio rerio
-
ovary low level of RNase Dre1 Danio rerio
-
skin
-
 Danio rerio
-
skin low level of RNase Dre1 Danio rerio
-
testis
-
 Danio rerio
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
RNA + H2O
-
 Danio rerio ?
-
 ?

Subunits

Subunits Comment Organism
? x * 23700, calculated from sequence Danio rerio
? x * 25400, calculated from sequence Danio rerio

Synonyms

Synonyms Comment Organism
ribonuclease T2
-
 Danio rerio
RNase Dre1
-
 Danio rerio
RNase Dre2
-
 Danio rerio
RNase T2
-
 Danio rerio

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
 at an acidic pH stronger activities in the 20-30 kDa range that may correspond to RNase T2 enzymes Danio rerio

Expression

Organism Comment Expression
Danio rerio RNase Dre2 expressed in all developmental stages and peaking at 72 h, signal is lower at 5 and 12 h up
Danio rerio strong expression of RNase Dre1 during all developmental stages analyzed (2, 5, 12, 24, 72 h after fertilization), with a peak of expression at 72 hours up

General Information

General Information Comment Organism
physiological function the zebrafish genome contains two RNase T2 genes, RNase Dre1 and RNase Dre2. These genes are part of two phylogenetic clades, one conserved in all chordates (the RNase Dre2 clade), and another fish-specific (the RNase Dre1 clade). RNase T2 enzymes carry out a housekeeping function Danio rerio