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Literature summary for 4.6.1.18 extracted from
- Site-specific RNase A activity was dramatically reduced in serum from multiple types of cancer patients (2014), PLoS ONE, 9, e96490.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Homo sapiens | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| serum | RNase activities are significantly reduced in serum samples of patients with gastric cancer, liver cancer, pancreatic cancer, esophageal cancer, ovary cancer, cervical cancer, bladder cancer, kidney cancer and lung cancer, while only minor changes are found in serum of breast and colon cancer patients compared to healthy controls. No difference in serum RNase levels between patients with primary and metastatic colon cancer | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | analysis of the site-specificity of serum RNases on double-stranded RNA substrates cleaving predominantly at 5'-U/A-3' and 5'-C/A-3' dinucleotide sites by real-time monitoring of RNase activity by fluorescence resonance energy transfer via short double strand RNA degradation | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RNase A | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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