Cloned (Comment) | Organism |
---|---|
RNase expression in CHO cells | Homo sapiens |
RNase expression in CHO cells | Bos taurus |
Protein Variants | Comment | Organism |
---|---|---|
N113S | the mutant N113S is more prominent in the Golgi than wild-type bovine RNase, which is mainly present in the endoplasmic reticulum | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Homo sapiens | - |
- |
extracellular | the enzyme is secreted | Bos taurus | - |
- |
additional information | analysis of synthesis and maturation, folding, quality control, and secretion, of pancreatic RNase in the endoplasmic reticulum of live cells, overview. Human RNase folds rapidly and is secreted mainly in glycosylated forms | Homo sapiens | - |
- |
additional information | analysis of synthesis and maturation, folding, quality control, and secretion, of pancreatic RNase in the endoplasmic reticulum of live cells, overview. In contrast to the slow in vitro refolding, the protein folds almost instantly after translation and translocation into the endoplasmatic reticulum lumen. Despite high stability of the native protein, only about half of the RNase reaches a secretion competent, monomeric form and is rapidly transported from the rough endoplasmic reticulum via the Golgi complex to the extracellular space, the rest remains in the endoplasmic reticulum mainly in the form of dimers and is slowly degraded | Bos taurus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | presence of N-glycans, one sequon for N-linked glycosylation | Bos taurus |
glycoprotein | presence of N-glycans, three sequons for N-linked glycosylation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreas | - |
Homo sapiens | - |
pancreas | - |
Bos taurus | - |
Subunits | Comment | Organism |
---|---|---|
monomer | - |
Bos taurus |
More | the secreted RNase in the bovine pancreas is mainly monomeric, whereas the enzyme present in the cells also contains 20% dimers | Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
pancreatic RNase | - |
Homo sapiens |
pancreatic RNase | - |
Bos taurus |
General Information | Comment | Organism |
---|---|---|
additional information | analysis of synthesis and maturation, folding, quality control, and secretion, of pancreatic RNase in the endoplasmic reticulum of live cells, overview. Human RNase folds rapidly and is secreted mainly in glycosylated forms | Homo sapiens |
additional information | analysis of synthesis and maturation, folding, quality control, and secretion, of pancreatic RNase in the endoplasmic reticulum of live cells, overview. In contrast to the slow in vitro refolding, the protein folds almost instantly after translation and translocation into the endoplasmatic reticulum lumen. Despite high stability of the native protein, only about half of the RNase reaches a secretion competent, monomeric form and is rapidly transported from the rough endoplasmic reticulum via the Golgi complex to the extracellular space | Bos taurus |