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Literature summary for 4.6.1.18 extracted from

  • Debnath, J.; Dasgupta, S.; Pathak, T.
    Nucleoside-amino acid conjugates: An alternative route to the design of ribonuclease A inhibitors (2009), Bioorg. Med. Chem., 17, 4921-4927.
    View publication on PubMed
Search for more literature for 4.6.1.18

Inhibitors

Inhibitors Comment Organism Structure
2',3'-dideoxy-3'-(gamma-aminobutyric acid)amino thymidine
-
 Bos taurus
2',3'-dideoxy-3'-D-leucylamino thymidine
-
 Bos taurus
2',3'-dideoxy-3'-glycylamino thymidine
-
 Bos taurus
2',3'-dideoxy-3'-L-alanylamino thymidine
-
 Bos taurus
2',3'-dideoxy-3'-L-histidinylamino thymidine
-
 Bos taurus
2',3'-dideoxy-3'-L-leucylamino thymidine
-
 Bos taurus
2',3'-dideoxy-3'-L-serinylamino thymidine occupies the active site of ribonuclease A and preferential perturbs the pKa value of His-119 by its free amino group as found from 1H NMR studies, compounds with polar amino acid side chains such as Ser-aT, Tyr-aT and Trp-aT (except His-aT) are more efficient inhibitors compared to those having hydrophobic side chains Bos taurus
2',3'-dideoxy-3'-L-tryptophanylamino thymidine compounds with polar amino acid side chains such as Ser-aT, Tyr-aT and Trp-aT (except His-aT) are more efficient inhibitors compared to those having hydrophobic side chains Bos taurus
2',3'-dideoxy-3'-L-tyrosylamino thymidine compounds with polar amino acid side chains such as Ser-aT, Tyr-aT and Trp-aT (except His-aT) are more efficient inhibitors compared to those having hydrophobic side chains Bos taurus
2',3'-dideoxy-3'-L-valinylamino thymidine
-
 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus P61823
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Bos taurus
-

Synonyms

Synonyms Comment Organism
ribonuclease A
-
 Bos taurus
RNase A
-
 Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.08
-
 2',3'-dideoxy-3'-L-serinylamino thymidine
-
 Bos taurus
0.451
-
 2',3'-dideoxy-3'-L-tyrosylamino thymidine
-
 Bos taurus